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Fig. 3 | Molecular Medicine

Fig. 3

From: Long noncoding RNA CASC2 inhibits ox-LDL-mediated vascular smooth muscle cells proliferation and migration via the regulation of miR-532-3p/PAPD5

Fig. 3

CASC2 sponged and sequestered miR-532-3p to up-regulate the expression of PAPD5. a The common binding sequences of miR-532-3p and PAPD5 by Targetscan analysis. b The luciferase activities of VSMCs co-transfected with miR-532-3p mimic and PAPD5-WT or PAPD5-MUT. c qRT-PCR for the expression of PAPD5 in VSMCs co-transfected with miR-532-3p mimic or miR-NC, and CASC2 or control. d Western blotting for the expression of PAPD5 protein in VSMCs co-transfected with miR-532-3p mimic or miR-NC, and CASC2 or control. e qRT-PCR for the expression of PAPD5 in serum of AS patients and healthy volunteers. f Pearson’s analysis of CASC2 and PAPD5 in serum of AS patients (r = 0.460, P < 0.001). * vs. control group, # vs. miR-532-3p mimics group. **P < 0.01, ##P < 0.01

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Molecular Medicine

ISSN: 1528-3658