The MC4R SNPs, their haplotypes and gene-environment interactions on the risk of obesity

Table 5 GMDR analysis of SNPs, haplotype and environment showed different interactions

Locus no.	Best combination	Training Bal. Acc	Testing Bal. Acc	Cross-validation consistency	P	^*P
SNP-environment interaction
2	WC + Age	0.8213	0.8213	10/10	< 0.001	< 0.001
3	WC+ drinking+ rs12970134	0.8256	0.8256	10/10	< 0.001	< 0.001
Haplotype-environment interaction
2	WC+ Age	0.8213	0.8213	10/10	< 0.001	< 0.001
3	WC+ drinking+ T-T-A	0.8232	0.8232	10/10	< 0.001	< 0.001

P, adjusting for sex, age, smoking, drinking, hypertension, hyperlipidemia, waist circumference (WC), and impaired fasting glucose. *P, indicates 1000 permutation tests. The haplotype is combined with MC4R rs17782313-rs476828-rs12970134

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