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Table 5 GMDR analysis of SNPs, haplotype and environment showed different interactions

From: The MC4R SNPs, their haplotypes and gene-environment interactions on the risk of obesity

Locus no. Best combination Training
Bal. Acc
Testing
Bal. Acc
Cross-validation
consistency
P *P
SNP-environment interaction
 2 WC + Age 0.8213 0.8213 10/10 <  0.001 <  0.001
 3 WC+ drinking+ rs12970134 0.8256 0.8256 10/10 <  0.001 <  0.001
Haplotype-environment interaction
 2 WC+ Age 0.8213 0.8213 10/10 <  0.001 <  0.001
 3 WC+ drinking+ T-T-A 0.8232 0.8232 10/10 <  0.001 <  0.001
  1. P, adjusting for sex, age, smoking, drinking, hypertension, hyperlipidemia, waist circumference (WC), and impaired fasting glucose. *P, indicates 1000 permutation tests. The haplotype is combined with MC4R rs17782313-rs476828-rs12970134