Table 6 Using logistic regression to analyze different types of interactions
From: The MC4R SNPs, their haplotypes and gene-environment interactions on the risk of obesity
Variable 1 | Variable 2 | OR (95% CI) | P |
|---|---|---|---|
SNP-environment interaction | |||
 rs12970134 | WC (male ≥90 cm, female ≥80 cm) |  |  |
 GG | No | 1 | – |
 GG | Yes | 42.577 (28.714–63.132) | <  0.001 |
 GA + AA | No | 1.07 (0.758–1.51) | 0.701 |
 GA + AA | Yes | 95.096 (47.260–191.351) | <  0.001 |
Haplotype-environment interaction | |||
 T-T-A | WC (male ≥90 cm, female ≥80 cm) |  |  |
 Non-carriers | No | 1 | – |
 Non-carriers | Yes | 51.371 (40.001–65.972) | <  0.001 |
 Carriers | No | 0.503 (0.246–1.027) | 0.059 |
 Carriers | Yes | 51.533 (12.131–218.912) | <  0.001 |