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Table 6 Using logistic regression to analyze different types of interactions

From: The MC4R SNPs, their haplotypes and gene-environment interactions on the risk of obesity

Variable 1 Variable 2 OR (95% CI) P
SNP-environment interaction
 rs12970134 WC (male ≥90 cm, female ≥80 cm)   
 GG No 1
 GG Yes 42.577 (28.714–63.132) <  0.001
 GA + AA No 1.07 (0.758–1.51) 0.701
 GA + AA Yes 95.096 (47.260–191.351) <  0.001
Haplotype-environment interaction
 T-T-A WC (male ≥90 cm, female ≥80 cm)   
 Non-carriers No 1
 Non-carriers Yes 51.371 (40.001–65.972) <  0.001
 Carriers No 0.503 (0.246–1.027) 0.059
 Carriers Yes 51.533 (12.131–218.912) <  0.001
  1. P, adjusting for sex, age, smoking, drinking, hypertension, hyperlipidemia, and impaired fasting glucose. T-T-A is combined with MC4R rs17782313-rs476828-rs12970134