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Fig. 3 | Molecular Medicine

Fig. 3

From: FK506 induces lung lymphatic endothelial cell senescence and downregulates LYVE-1 expression, with associated decreased hyaluronan uptake

Fig. 3

FK506 induces LYVE-1 downregulation. a) Real-time PCR analysis of LYVE-1 mRNA in control and FK506-treated (48 h) lung lymphatic endothelial cells. Results were expressed as the fold change compared to control. Graphs represent the mean ± SE from three independent experiments (** < 0.01 one-way ANOVA). Whole lysates of lung lymphatic endothelial cells were subjected to Western blot analysis with antibodies against LYVE-1 and β-actin (b). Ratio of LYVE-1 (c) to β-actin density was expressed as fold-change relative to control. Data represent mean ± SEM of three independent experiments, consisting of one technical replicate each. **p < 0.01 by one-way ANOVA

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Molecular Medicine

ISSN: 1528-3658