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Fig. 1 | Molecular Medicine

Fig. 1

From: Exosomal miR-223 derived from natural killer cells inhibits hepatic stellate cell activation by suppressing autophagy

Fig. 1

NK-Exo attenuated TGF-β1-induced HSC activation by transferring miR-223. a The relative expression of miR-223 determined by qRT-PCR in NK-92MI cells and NK-92MI cell-derived exosomes (NK-Exo). **P < 0.01 vs. NK cell. b The relative expression of miR-223 determined by qRT-PCR in exosomes derived from NK-92MI cells transfected with inhibitor NC (NK-Exo-NC) or miR-223 inhibitor (NK-Exo-miR-223I). **P < 0.01 vs. NK-Exo-NC. The relative expression of miR-223 determined by qRT-PCR (c), cell proliferation ratio determined by CCK-8 assay (d), the mRNA (e) and protein (f) levels of α-SMA and CoL1A1 in LX-2 cells in the groups of Control, TGF-β1, TGF-β1 + PBS, TGF-β1 + NK-Exo, TGF-β1 + NK-Exo-NC, and TGF-β1 + NK-Exo-miR-223I. *P < 0.05, **P < 0.01 vs. Control; #P < 0.05, ##P < 0.01 vs. TGF-β1 + PBS; &P < 0.05, &&P < 0.01 vs. TGF-β1 + NK-Exo-NC. The data are presented as the mean ± standard deviation (n = 3)

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