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Fig. 2 | Molecular Medicine

Fig. 2

From: Exosomal miR-223 derived from natural killer cells inhibits hepatic stellate cell activation by suppressing autophagy

Fig. 2

NK-Exo-mediated transfer of miR-223 attenuated TGF-β1-induced HSC activation by inhibiting autophagy. a The protein levels of autophagy-related proteins including p62, Beclin-1, LC3-I, LC3-II in LX-2 cells in the groups of Control, TGF-β1, TGF-β1 + PBS, TGF-β1 + NK-Exo, TGF-β1 + NK-Exo-NC, and TGF-β1 + NK-Exo-miR-223I. *P < 0.05, vs. Control; #P < 0.05, vs. TGF-β1 + PBS; &P < 0.05, vs. TGF-β1 + NK-Exo-NC. Cell proliferation ratio determined by CCK-8 assay (b), the mRNA (c) and protein (d) levels of α-SMA and CoL1A1 in LX-2 cells in the groups of TGF-β1 + PBS, TGF-β1 + NK-Exo, TGF-β1 + NK-Exo + DMSO and TGF-β1 + NK-Exo + rapamycin. *P < 0.05, **P < 0.01 vs. TGF-β1 + PBS; #P < 0.05, ##P < 0.01 vs. TGF-β1 + NK-Exo + DMSO. The data are presented as the mean ± standard deviation (n = 3)

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Molecular Medicine

ISSN: 1528-3658