Fig. 2
From: Knockdown of lincRNA PADNA promotes bupivacaine-induced neurotoxicity by miR-194/FBXW7 axis
Function of lincRNA PADNA in bupivacaine-induced neurotoxicity. a The expressions of lincRNA PADNA were significantly decreased in DRG neurons treated with siRNA3 or siRNA4 when compared with blank group, NC group, DRG neurons treated with siRNA1 or siRNA2. b Cell viability was significantly decreased in DRG neurons treated with knockdown vector of lincRNA PADNA. Cells were treated with 1 mM bupivacaine. c Percentage of apoptotic of cells was significantly increased in DRG neurons treated with knockdown vector of lincRNA PADNA. Cells were treated with 1 mM bupivacaine. d Caspase3 activity was significantly increased in DRG neurons treated with knockdown vector of lincRNA PADNA. Cells were treated with 1 mM bupivacaine. e, f The expression of Caspase3 protein was significantly increased in DRG neurons treated with knockdown vector of lincRNA PADNA. Cells were treated with 1 mM bupivacaine. Data are Mean ± SD with n = 3 independent biological cultures. *p < 0.05 and ** p < 0.01