Fig. 3From: Knockdown of lincRNA PADNA promotes bupivacaine-induced neurotoxicity by miR-194/FBXW7 axismiR-194 is the direct target of lincRNA PADNA. a The predicted binding sequence of lincRNA PADNA and miR-194. b The relative luciferase activity was significantly reduced in DRG neurons co-transfected with wt-lincRNA PADNA vector and miR-194 mimics than in DRG neurons co-transfected with mut-lincRNA PADNA vector or empty vector or mimic NC. c Overexpression of miR-194 distinctly reduced the expression of lincRNA PADNA in DRG neurons. d Overexpression of miR-194 distinctly reduced the expression of lincRNA PADNA in HEK293 cells. e The relative expression of miR-194 was manifestly reduced with the increase of concentration of bupivacaine. Data are Mean ± SD with n = 3 independent biological cultures. *p < 0.05 and ** p < 0.01Back to article page