Skip to main content
Fig. 3 | Molecular Medicine

Fig. 3

From: SHP2 inhibitor PHPS1 ameliorates acute kidney injury by Erk1/2-STAT3 signaling in a combined murine hemorrhage followed by septic challenge model

Fig. 3

Effects of SHP2 inhibition by PHPS1 treatment on kidney injury after Hem/CLP. The plasm samples were collected 24 h post Hem/CLP or Sham operation for urea nitrogen (BUN) (a), creatinine (SCr) (b), NGAL (c) and cleaved caspase 3 (d). Vehicle treated Hem/CLP mice showed significantly increased in BUN, SCr, NGAL and cleaved caspase 3 levels compared to Sham mice. However, these increases were markedly reduced in PHPS1 treated Hem/CLP mice. *, P < 0.05, versus Sham (S/S); #, P < 0.05, PHPS1 treated group (Hem/CLP + PHPS1) versus Hem/CLP + vehicle (Hem/CLP). One-way ANOVA and a Student-Newman-Keuls’ test, Mean ± SD; n = 6 mice/group

Back to article page