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Fig. 4 | Molecular Medicine

Fig. 4

From: SHP2 inhibitor PHPS1 ameliorates acute kidney injury by Erk1/2-STAT3 signaling in a combined murine hemorrhage followed by septic challenge model

Fig. 4

Effects of SHP2 inhibition on kidney histopathologic changes after Hem/CLP. The kidneys were collected 24 h post Hem/CLP or Sham operation. Representative H&E staining of kidney sections for detection of injury by pathological changes. Compared to S/S group (a), the kidney from Hem/CLP mice (b) exhibited tubular epithelial cell sloughing/detachment (black arrows), edema, inflammatory cell infiltration, loss of brush borders, tubular dilation, and tubular distortion, examined under light microscopy (20X) (scale bar: 50 μm). However, PHPS1 treatment markedly ameliorated these changes and preserved the renal architecture (c). The summary data of injury score of 3–5 fields/slide/sample at 200x magnification (d). *, P < 0.05, versus Sham (S/S); #, P < 0.05, PHPS1 treated group (Hem/CLP + PHPS1) versus Hem/CLP + vehicle (Hem/CLP). One-way ANOVA and a Student-Newman-Keuls’ test, Mean ± SD; n = 6 mice/group

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Molecular Medicine

ISSN: 1528-3658