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Fig. 6 | Molecular Medicine

Fig. 6

From: SHP2 inhibitor PHPS1 ameliorates acute kidney injury by Erk1/2-STAT3 signaling in a combined murine hemorrhage followed by septic challenge model

Fig. 6

Effects of PHPS1 on expression of HMGB1 in kidney after Hem/CLP. The kidneys were collected 24 h post Hem/CLP or Sham operation and tissue homogenates were obtained. The expression of HMGB1 was determined by western blot. The levels of HMGB1 from Hem/CLP mice was significantly increased compared to Shams. PHPS1 treated Hem/CLP mice showed reduced HMGB1 levels compared to Veh treated HEM/CLP mice. *, P < 0.05, versus Sham (S/S); #, P < 0.05, PHPS1 treated group (Hem/CLP + PHPS1) versus Hem/CLP + vehicle (Hem/CLP). One-way ANOVA and a Student-Newman-Keuls’ test, Mean ± SD; n = 6 mice/group

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