Table 1 Effects of Aim2 expression/knockout on VSMC differentiation and aortic remodeling
VSMC Genotype | Aim2 −/− | WT |
|---|---|---|
Rankl/Tnfsf11 expression | low | high |
Bmp4 expression | high | low |
Calcification in mineralization medium (OM) | high | low |
Osteochondrogenic differentiation | Osteoblast-like | Osteoclast-like |
Role in AAA | Anabolic calcification; reduced incidence of aortic dilation | Catabolic degradation; high incidence of aortic dilation |
Nlrp3 expression | low | high |
Il1b expression | low | high |
NF-κB (p65) activity | low | high |
Il-6 release | low | high |
Inflammatory response | low | high |