Fig. 3
From: The role of host defences in Covid 19 and treatments thereof
Possible interventions to boost the HO-1/CO/H2S axis. The HO-1/CO/H2S axis can be modulated at various steps. HO-1 inducers may increase the expression and activity of the enzyme resulting in faster activation of CO release; CO delivery may compensate a defective delivery from HO-1 reactions; A boost to the endogenous H2S synthesis would compensate a defective activation of the alternative pathways of CBS and CSE; Direct delivery of H2S may increase availability and actions from H2S independently of the above passages; Delivery of persulfides, although not substituting all the functions of H2S, may be sufficient for the action on the KATP channels. Multiple interventions targeting different steps of the process might be considered