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Table 1 Characteristics of subjects selected for DNA methylation analysis

From: DNA methylation microarrays identify epigenetically regulated lipid related genes in obese patients with hypercholesterolemia

  Hypercholesterolemia group (n = 5) Control group (n = 5) p-value
Age (years) 43.0 ± 12.6 44.6 ± 10.6 0.83
Sex, female (%)b 60 60 ns
Weight (kg)a 88 (80–107.7) 89.2 (80.2–103.2) 1
Adipose tissue mass (%)a 38.3 (30.55–43.25) 37.4 (30.9–45.3) 0.47
BMI (kg/m2) 34.0 (29.47–36.9) 31.7 (28.4–38.9) 0.676
WHRa 0.9 (0.81–0.95) 0.81 (0.79–0.82) 0.11
Systolic blood pressure (mmHg)a 130 (127.5–140) 124 (119–130) 0.095
Diastolic blood pressure (mmHg)a 80 (80–90) 80 (77–86) 0.53
Total cholesterol (mmol/L)a 6.31 (5.58–6.64) 5.0 (4.5–5.25) 0.06
LDL cholesterol (mmol/L)a 4.27 (3.9–4.8) 2.74 (2.5–2.95) < 0.001
HDL cholesterol (mmol/l)a 1.2 ± 0.3 1.4 ± 0.3 0.25
Non-HDL (mmol/L)a 5.19 (4.53–5.37) 3.49 (2.99–4.11) 0.02
Fasting triglycerides (mmol/L) 1.7 ± 0.7 1.1 ± 0.8 0.26
Total fatty acids (µg/mL) 4118 ± 1226 3341 ± 925 0.31
Saturated fatty acids (%) 34.04 ± 1.96 32.09 ± 0.85 0.08
Monounsaturated fatty acids (%) 28.52 ± 4.35 26.42 ± 4.42 0.49
Polyunsaturated fatty acids (%) 37.43 ± 6.02 41.49 ± 4.37 0.28
Fasting glucose (mmol/L)a 5.8 (5.1–6.3) 4.9 (4.7–5.8) 0.4
Glucose AUC OLTT (mmol/L min)a 10.44 (10.0–10.72) 9.05 (8.78–9.77) 0.022
Glucose AUC OGTT (mmol/L min)a 4.4 (3.2–5.0) 3.26 (2.6–3.45) 0.06
Fasting insulin (µIU/mL) 22.8 ± 16.8 11.3 ± 4.2 0.173
HOMA-IR 4.0 ± 1.6 2.6 ± 1.1 0.14
Adiponectin (µg/mL)a 4.2 (3.55–8.07) 7.4 (5.58–10.0) 0.21
Leptin (ng/mL)a 29.89 (15.18–46.04) 21.8 (14.16–101.85) 0.83
Fasting GIP (pg/mL)a 32.54 (12.3–48.8) 24.1 (18.1–37.43) 0.4
FGF19 (pg/mL) 160.8 ± 61.7 151.4 ± 108.7 0.62
FGF21 (pg/mL) 280.4 ± 144.3 138.8 ± 92.5 0.102
  1. Comparison between the high LDL-CH group and controls (unpaired t-test for normally or Mann–Whitney U-test for non-normally distributed a variables). Data shown as mean ± SD; otherwise (a) as median and interquartile range in parentheses except nominal variable (b) shown as % of subjects. b The chi-squared test was used for nominal variable. The statistically significant results are marked in italics