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Fig. 7 | Molecular Medicine

Fig. 7

From: Fibroblast growth factor-2 alleviates the capillary leakage and inflammation in sepsis

Fig. 7

FGF2 alleviates the inflammation and vascular leakage in sepsis. FGF2 reduces vascular leakage caused by relieving inflammation through AKT/P38/NF-κB pathways. a LPS combined with TLR4 activates AKT/P38/NF-κB pathways to release amount of inflammatory factors leading to VE-cadherin/α-E-catenin disruption and endothelial cell barrier malfunction. b FGF2 enhances vascular barrier function against inflammatory factors production by inactivating AKT/P38/NF-κB pathways and stabilizing VE-cadherin/α-E-catenin at the cell surface

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