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Table 1 Studies selected for meta-analysis

From: Meta-analysis of metabolites involved in bioenergetic pathways reveals a pseudohypoxic state in Down syndrome

Study

# of DS

# of CTR

Analytes measured

Biological matrix

Antonaros et al. (2020)

129

46

Citrate, glucose, glutamine, lactate, pyruvate, succinate, tyrosine

Plasma

Bartels (1971)

15

15

ATP, ADP, AMP

RBC

Bayer and McCoy (1974)

8

19

ATP, ADP, AMP

Platelet

Campos et al. (2010)

38

28

Uric acid

Urine

Caracausi et al. (2018)

51

20

Citrate, tyrosine

Plasma, urine

Chapman and Stern (1964)

40

40

Uric acid

Serum

Convertini et al. (2016)

3–6

3–6

Citrate

Lymphoblast, PBMC

Coppus et al. (2007)

46

48

Tyrosine, serine

Plasma

Culp-Hill et al. (2017)

29

43

Citrate, glucose, lactate, pyruvate, serine, succinate, tyrosine, uric acid, 2,3-DPG, ADP, AMP, arginine, ATP, glutamine, homocysteine, Pi

RBC

de Asua et al. (2014a,b)

48

33

Glucose

Plasma

de Sousa et al. (2015)

30

30

Uric acid

Saliva

Fuller et al. (1962)

80

80

Uric acid

Serum

Heggarty et al. (1996)

21–22

18–20

Arginine, cysteine, glutamine, serine, tyrosine

Plasma, urine

Helguera et al. (2013)

10

10

ATP

Neuron

Howell et al. (1973)

113

106

Uric acid

Serum, urine

Infantino et al. (2011)

6

6

Cysteine, serine

WBC

Izzo et al. (2017)

5

4

ATP

Fibroblast

Kaufman and O’Brien (1967)

107

107

Uric acid

Serum

Kedziora et al. (1972)

6

7

ATP, ADP, AMP, Pi, 2,3-diphosphoglycerate

RBC

Knull et al. (1978)

19

22

ATP, 2,3-diphosphoglycerate

RBC

Lejeune et al. (1992)

79

206

Serine, cysteine, tyrosine, arginine

Plasma

Mertz et al. (1963)

25

25

Uric acid

Serum

Miles et al. (2007)

14

12

CoQ10

Plasma

Mircher et al. (1997)

107

216

Serine, tyrosine, arginine

Plasma, urine

Nelson and Benson (1972)

20

20

2,3-diphosphoglycerate

RBC

Nura et al. (2008)

48

37

Serine, glutamine, arginine

Plasma

Obeid et al. (2012)

35

47

Cysteine, homocysteine

Plasma, ferum

Orozco et al. (2019)

31

193

Serine, lactate, pyruvate, tyrosine, glutamine, succinate, arginine

Plasma

Pant et al. (1968)

356

360

Uric acid

Plasma

Pogribna et al. (2001)

42

36–38

Cysteine, homocysteine

Plasma

Powers et al. (2019)

72–75

79–90

Citrate, glucose, arginine, cysteine, glutamine, homocysteine, serine, tyrosine, lactate, Pi, pyruvate, succinate, uric acid

Plasma

Puukka et al. (1982)

10

10

ATP, ADP, AMP

RBC

Rodríguez-Sureda et al. (2015)

5

5

ATP

Fibroblast

Rosner et al. (1965)

12

12

Pi, uric acid

Serum

Stocchi et al. (1985)

20

20

ATP, ADP, AMP

RBC

Tiano et al. (2008)

30

30

CoQ10, uric acid

Lymph, plasma, platelets

Valenti et al. (2010)

5

5

Lactate, ATP, ADP, AMP

Fibroblast

Watkins et al. (1989)

15–18

19

Serine, tyrosine, cysteine, arginine

Plasma

Yates et al. (1990)

6

29–30

Lactate

Caudate nucleus, frontal cortex

Zaki et al. (2017)

43

43

CoQ10, glucose

Plasma

Zitnanova et al. (2004)

16

16

Uric acid

Plasma