Skip to main content

Table 1 Studies selected for meta-analysis

From: Meta-analysis of metabolites involved in bioenergetic pathways reveals a pseudohypoxic state in Down syndrome

Study # of DS # of CTR Analytes measured Biological matrix
Antonaros et al. (2020) 129 46 Citrate, glucose, glutamine, lactate, pyruvate, succinate, tyrosine Plasma
Bartels (1971) 15 15 ATP, ADP, AMP RBC
Bayer and McCoy (1974) 8 19 ATP, ADP, AMP Platelet
Campos et al. (2010) 38 28 Uric acid Urine
Caracausi et al. (2018) 51 20 Citrate, tyrosine Plasma, urine
Chapman and Stern (1964) 40 40 Uric acid Serum
Convertini et al. (2016) 3–6 3–6 Citrate Lymphoblast, PBMC
Coppus et al. (2007) 46 48 Tyrosine, serine Plasma
Culp-Hill et al. (2017) 29 43 Citrate, glucose, lactate, pyruvate, serine, succinate, tyrosine, uric acid, 2,3-DPG, ADP, AMP, arginine, ATP, glutamine, homocysteine, Pi RBC
de Asua et al. (2014a,b) 48 33 Glucose Plasma
de Sousa et al. (2015) 30 30 Uric acid Saliva
Fuller et al. (1962) 80 80 Uric acid Serum
Heggarty et al. (1996) 21–22 18–20 Arginine, cysteine, glutamine, serine, tyrosine Plasma, urine
Helguera et al. (2013) 10 10 ATP Neuron
Howell et al. (1973) 113 106 Uric acid Serum, urine
Infantino et al. (2011) 6 6 Cysteine, serine WBC
Izzo et al. (2017) 5 4 ATP Fibroblast
Kaufman and O’Brien (1967) 107 107 Uric acid Serum
Kedziora et al. (1972) 6 7 ATP, ADP, AMP, Pi, 2,3-diphosphoglycerate RBC
Knull et al. (1978) 19 22 ATP, 2,3-diphosphoglycerate RBC
Lejeune et al. (1992) 79 206 Serine, cysteine, tyrosine, arginine Plasma
Mertz et al. (1963) 25 25 Uric acid Serum
Miles et al. (2007) 14 12 CoQ10 Plasma
Mircher et al. (1997) 107 216 Serine, tyrosine, arginine Plasma, urine
Nelson and Benson (1972) 20 20 2,3-diphosphoglycerate RBC
Nura et al. (2008) 48 37 Serine, glutamine, arginine Plasma
Obeid et al. (2012) 35 47 Cysteine, homocysteine Plasma, ferum
Orozco et al. (2019) 31 193 Serine, lactate, pyruvate, tyrosine, glutamine, succinate, arginine Plasma
Pant et al. (1968) 356 360 Uric acid Plasma
Pogribna et al. (2001) 42 36–38 Cysteine, homocysteine Plasma
Powers et al. (2019) 72–75 79–90 Citrate, glucose, arginine, cysteine, glutamine, homocysteine, serine, tyrosine, lactate, Pi, pyruvate, succinate, uric acid Plasma
Puukka et al. (1982) 10 10 ATP, ADP, AMP RBC
Rodríguez-Sureda et al. (2015) 5 5 ATP Fibroblast
Rosner et al. (1965) 12 12 Pi, uric acid Serum
Stocchi et al. (1985) 20 20 ATP, ADP, AMP RBC
Tiano et al. (2008) 30 30 CoQ10, uric acid Lymph, plasma, platelets
Valenti et al. (2010) 5 5 Lactate, ATP, ADP, AMP Fibroblast
Watkins et al. (1989) 15–18 19 Serine, tyrosine, cysteine, arginine Plasma
Yates et al. (1990) 6 29–30 Lactate Caudate nucleus, frontal cortex
Zaki et al. (2017) 43 43 CoQ10, glucose Plasma
Zitnanova et al. (2004) 16 16 Uric acid Plasma