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Table 2 Relative gene expression of hepatic CPT-1, MCAD, LCAD and VLCAD in WT and HC-HMGB1-KO mice on LFD or HFD for 8 weeks

From: Hepatocyte high-mobility group box 1 protects against steatosis and cellular stress during high fat diet feeding

Gene

mRNA relative expression

LFD

HFD

WT

HC-HMGB1−/−

P value

WT

HC-HMGB1−/−

P

value

β-oxidation

 CPT-1α

1.24 ± 0.46

0.63 ± 0.24

0.069

0.98 ± 0.14

0.56 ± 0.18

0.010

 MCAD

1.08 ± 0.35

0.57 ± 0.15

0.052

1.26 ± 0.20

0.48 ± 0.07

0.002

 LCAD

0.97 ± 0.14

0.91 ± 0.07

0.450

0.99 ± 0.14

0.52 ± 0.14

0.003

 VLCAD

1.01 ± 0.34

0.49 ± 0.27

0.054

0.91 ± 0.021

0.41 ± 0.0

 < 0.001

Lipogenesis

 FAS

0.96 ± 0.05

0.87 ± 0.32

0.610

0.93 ± 0.41

0.78 ± 0.18

0.550

 PPAR-γ

0.96 ± 0.04

0.70 ± 0.24

0.120

1.87 ± 0.66

1.69 ± 0.17

0.630

 SCD-1

1.01 ± 0.29

1.47 ± 0.39

0.110

0.80 ± 0.10

2.32 ± 0.98

0.053

 Adipophilin

0.89 ± 0.21

0.41 ± 0.38

0.091

2.78 ± 1.99

0.44 ± 0.49

0.096

Lipolysis

 LPL

1.18 ± 0.25

0.28 ± 0.30

0.004

0.16 ± 0.15

0.40 ± 0.17

0.079

 SREBP1

1.42 ± 0.21

1.16 ± 0.21

0.130

0.96 ± 0.29

0.62 ± 0.14

0.098

  1. n = 4 for each group; data presented as mean ± SEM