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Fig. 5 | Molecular Medicine

Fig. 5

From: Silencing long non-coding RNA XIST suppresses drug resistance in acute myeloid leukemia through down-regulation of MYC by elevating microRNA-29a expression

Fig. 5

Down-regulated XIST elevated miR-29a and reduced MYC to inhibit tumorigenic ability of KG-1 cells in nude mice. a The volume of tumor in nude mice. b The weight of tumor in nude mice. c, d The expression of apoptosis-related genes (Bcl-2, Bax and Cleaved-caspase-3) in KG-1 cells determined by Western blot analysis. * p < 0.05 vs. nude mice bearing KG-1 cells treated with PBS alone or nude mice bearing KG-1 cells treated with si-NC + oe-NC. The data were all measurement data, and expressed as mean ± standard deviation. Tumor volume was analyzed by repeated measures ANOVA, and tumor weight was analyzed by one-way ANOVA, n = 6. The experiment was repeated 3 times independently

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Molecular Medicine

ISSN: 1528-3658