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Table 2 Laboratory findings of 74 severe and critically ill patients

From: IP-10 and MCP-1 as biomarkers associated with disease severity of COVID-19

Laboratory findings Total (N = 74) Severe patients (N = 19) Critically ill patients (N = 55) P
n Median (IQR) n Median (IQR) n Median (IQR)
ELISA
 IP-10, pg/mL 74 364.8 (203.7–939.4) 19 193.1 (123.0–300.5) 55 531.3 (278.0–1217.3)  < 0.001
 MCP-1, pg/mL 73 642.2 (293.2–1207.5) 18 230.7 (137.9–338.7) 55 837.0 (425.6–1374.0)  < 0.001
 MIP1a, pg/mL 74 28.6 (15.2–79.7) 19 25.5 (13.8–86.1) 55 30.6 (16.4–77.6) 0.338
Cytokines
 IL-1β, pg/mL 29 5.0 (5.0–5.0) 4 5.0 (5.0–5.0) 25 5.0 (5.0–5.9) 0.284
 IL-2R, U/mL 30 1055.5 (464.5–1609.5) 5 740.0 (325.0–1314.5) 25 1258.0 (518.5–1820.0) 0.331
 IL-6, pg/mL 48 74.2 (17.0–157.5) 13 10.4 (5.4–31.1) 35 103.0 (43.0–323.2)  < 0.001
 IL-8, pg/mL 29 51.7 (12.5–114.7) 4 11.1 (8.1–60.8) 25 62.3 (19.9–142.5) 0.077
 IL-10, pg/mL 29 11.4 (5.0–20.1) 4 5.0 (5.0–8.0) 25 11.9 (5.0–25.1) 0.049
 TNFα, pg/mL 27 12.7 (7.5–28.7) 4 7.8 (6.4–9.1) 23 13.3 (7.5–30.3) 0.414
Hematologic parameters
 Platelets, × 109/mL 72 132.5 (70.8–232.0) 17 254.0 (158.5–370.5) 55 88.0 (56.0–191.0)  < 0.001
 Platelet distribution width (PDW), fL 64 14.4 (12.9–16.6) 17 13.4 (11.5–14.4) 47 14.5 (13.1–18.6)  < 0.001
 Mean platelet volume (MPV), fL 64 11.6 (11.0–12.6) 17 11.2 (10.3–11.7) 47 11.9 (11.2–13.1) 0.005
 Platelet larger cell ratio (P-LCR), % 64 37.9 (33.1–45.2) 17 33.2 (26.9–38.2) 47 40.3 (34.2–47.6) 0.003
 Plateletcrit (PCT), % 64 0.19 (0.10–0.26) 17 0.28 (0.19–0.37) 47 0.13 (0.08–0.23)  < 0.001
Coagulation function
 Prothrombin time (PT), s 71 15.9 (14.9–18.2) 17 14.9 (14.0–15.6) 54 16.9 (15.5–18.5)  < 0.001
 Prothrombin activity (PTA), % 71 69.0 (55.0–80.0) 17 80.0 (72.5–89.0) 54 63.0 (53.3–72.5)  < 0.001
 International normalized ratio (INR) 71 1.26 (1.15–1.49) 17 1.15 (1.07–1.23) 54 1.36 (1.22–1.54)  < 0.001
 Fibrinogen (FIB), g/L 71 4.2 (3.1–5.2) 17 4.2 (3.5–4.9) 54 4.2 (3.0–5.3) 0.845
 Activated partial thromboplastin time (APTT), s 71 44.5 (39.3–52.6) 17 41.5 (37.0–46.6) 54 46.4 (40.7–53.9) 0.089
 Thrombin time (TT), s 71 15.3 (14.5–16.5) 17 15.0 (14.3–15.7) 54 15.5 (14.7–16.9) 0.083
 d-dimer, μg/mL FEU 71 3.9 (1.7–13.5) 17 2.4 (1.3–3.6) 54 6.2 (2.3–15.2) 0.006
 Fibrin degradation products (FDP), μg/mL 30 17.2 (6.2–68.6) 6 4.9 (4.0–7.8) 24 33.6 (13.6–102.6) 0.003
 Antithrombin (AT), % 34 80.5 (65.5–88.5) 8 85.0 (74.3–93.0) 26 78.5 (63.0–86.5) 0.219
  1. Bold indicates the statistically significant values (P < 0.05)