Table 1 Gut microbiota influences miRNAs in host pathophysiology
From: The roles of the gut microbiota–miRNA interaction in the host pathophysiology
Pathophysiology | MiRNA | Targets | Cell signaling pathways | References |
|---|---|---|---|---|
IESC proliferation | miR-375-3P | (Peck et al. 2017) | ||
IECS permeability | miR-21-5P | PTEN&PDCD4 | ARF4 | (Nakata et al. 2017) |
IBD&CRC | miR-155 | (Rodríguez-Nogales et al. 2017) | ||
miR-233 | ||||
miR-150 | ||||
miR-143 | ||||
miR-18a* | ULK1 | TLR4&MYD88 | (Yu et al. 2017) | |
miR-4802 | ATG7 | TLR4&MYD88 | ||
miR-20a-5P | SENP1 | P53 | (Dalmasso et al. 2014) | |
miR-183-5P | (Hoban et al. 2017) | |||
CNS | miR-182-5P | |||
miR-206-3P | BDNF signaling | |||
miR-294-5P | Brd2&Slit3kr | Kynurenine pathway | (Moloney et al. 2017) | |
miR-146a | CFH,TREM2, SHANK3 | NF-κB | ||
Immune system | miR-10a | IL-12/IL23P40 | MyD88 pathway | (Xue et al. 2011) |
miR-146b | (Pang et al. 2018) | |||
miR-29c | ||||
let-7b | TLR4 signaling | (Guo et al. 2018) | ||
miR-130a | TNF-α | (Shi et al. 2018) | ||
Cardiovascular disease | miR-10b | ABCG1&ABCA1 | (Wang et al. 2012) | |
miR-204 | Sirt1 | Stat3 | (Vikram et al. 2016) |