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Fig. 2 | Molecular Medicine

Fig. 2

From: Downregulation of long noncoding RNA DLEU1 attenuates hypersensitivity in chronic constriction injury-induced neuropathic pain in rats by targeting miR-133a-3p/SRPK1 axis

Fig. 2

DLEU1 knockdown suppressed neuroinflammation and attenuated neuropathic pain-like behaviors. a The concentrations of IL‐6, TNF‐α and IL-1β in the dorsal spinal cord of rats were detected by ELISA at postoperative Day 7. N = 8 for each group. b The effect of DLEU1 knockdown on behavioral nociceptive responses to mechanical stimuli was assessed by paw withdrawal mechanical threshold (PWT) at postoperative days 0, 7, 14 and 21. N = 8 for each group. c The effect of DLEU1 knockdown on behavioral nociceptive responses to thermal hypersensitivity was evaluated by paw withdrawal latency (PWL) at postoperative days 0, 7, 14 and 21. N = 8 for each group. *p < 0.05, &p < 0.05

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Molecular Medicine

ISSN: 1528-3658