Fig. 5

Hdac3 potentiates the transcription and the expression of Pgf via the miR-17-EZH1-p65 axis in primary lung fibroblasts of BPD mice. a The expression of Pgf assayed by RT-qPCR and Western blot analysis in cells transfected with sh-Hdac3, miR-17 inhibitor or both. b The enrichment of p65 in Pgf promoter region assayed by ChIP assay in cells transfected with sh-Hdac3, miR-17 inhibitor or both. *p < 0.05 compared to sh-NC or inhibitor NC. The above data were expressed as mean ± standard deviation. Data among multiple groups were analyzed by one-way ANOVA, followed by Tukey’s post-hoc test