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Fig. 7 | Molecular Medicine

Fig. 7

From: Involvement of Hdac3-mediated inhibition of microRNA cluster 17-92 in bronchopulmonary dysplasia development

Fig. 7

Schematic diagram depicting the role of Hdac3 regulating the miR-17-EZH1-p65-Pgf axis in BPD in neonatal mice. Hdac3 is highly expressed in lung fibroblasts of BPD mice, inhibiting the expression of miR-17 in the miR-17-92 cluster. In addition, Hdac3 attenuates the binding of miR-17 to EZH1, and consequently upregulates the transcription and expression of Pgf, a downstream target gene of transcription factor p65. This thereby promotes angiogenesis and alveolar formation, and aggravates the progression of BPD

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Molecular Medicine

ISSN: 1528-3658