Skip to main content
Fig. 3 | Molecular Medicine

Fig. 3

From: Increased H3K4me3 methylation and decreased miR-7113-5p expression lead to enhanced Wnt/β-catenin signaling in immune cells from PTSD patients leading to inflammatory phenotype

Fig. 3

Micro-RNA expression analysis in PTSD patients. Microarray was performed on 6 controls and 6 PTSD patients each. a Heat map showing the normalized expression intensities of the miRNAs in controls and PTSD patients (C1–C6: Control, P1–P6: PTSD). b Dysregulated miRNAs were used for miRNA target gene identification in Ingenuity Pathway Analysis tool, Qiagen. The green color miRNAs are down regulated in PTSD and red color indicate those that are upregulated. c Nucleotide pairing schema for miR-7113-5p and WNT10B 3′UTR obtained from TargetScan. d RT-qPCR validation of hsa-miR-7113-5p expression in 24 controls and PTSD patients each. WNT10B transcript (e) and protein (f) levels in THP1 cells 48 h after transfection with hsa-miR-7113-5p mimics. The values in panel f indicate the normalized ratios of the different samples

Back to article page

Molecular Medicine

ISSN: 1528-3658