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Fig. 4 | Molecular Medicine

Fig. 4

From: Increased H3K4me3 methylation and decreased miR-7113-5p expression lead to enhanced Wnt/β-catenin signaling in immune cells from PTSD patients leading to inflammatory phenotype

Fig. 4

WNT10B-mediated effect on expression of proinflammatory genes. PBMCs from control individuals were cultured for indicated time with/without rh-WNT10B (200 ng/ml) after pre-activation of the cells with PMA (200 µM). ad qRT-PCR results showing expression of Tbx-21 and IFNγ after WNT10B addition compared to activated PBMCs after the indicated time of culture. e IFNγ was measured in the culture supernatants after 24 h of WNT10B addition. f Inflammatory gene expression levels after blocking WNT signaling by IWR1 for the indicated time period. The first vertical bars represent controls against which the experiments were compared for fold change calculation. (IWR: IWR1, WNT signaling inhibitor)

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