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Fig. 2 | Molecular Medicine

Fig. 2

From: PTEN inhibitor improves vascular remodeling and cardiac function after myocardial infarction through PI3k/Akt/VEGF signaling pathway

Fig. 2

PTEN inhibitor improved cardiac functional in MI mice. Mice were injected intravenously with BVP (a selective inhibitor of PTEN, 1.0 mg/kg) 1 h after LAD ligation. MI mice were then administrated daily in the following 6 days. The effects of PTEN inhibitor on cardiac were examined on day 14 by Echocardiographic analysis in different groups. a Left ventricular ejection fraction (LVEF). Hemodynamic parameter + dp/dtmax (b) and LV end diastolic pressure (LVEDP) (c). n = 8 for each group. d Representative Masson’s trichrome-stained myocardial sections in the treated MI hearts. Blue, scar tissue; dark-red, viable myocardium. e Quantitation of infarcted size in the three indicated experimental groups. Data were represented as means ± SEM. **p < 0.01, ***p < 0.001, ns no significant difference, n = 8 for each group

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