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Fig. 3 | Molecular Medicine

Fig. 3

From: Targeting the eCIRP/TREM-1 interaction with a small molecule inhibitor improves cardiac dysfunction in neonatal sepsis

Fig. 3

M3 improves pulmonary and cardiac inflammation. 16 h after cecal slurry sepsis induction, mRNA and protein levels of proinflammatory cytokines were measured by RT-PCR and ELISA. Lung levels of IL-6 and IL-1β (a, b) mRNA and (c, d) protein were increased by sepsis and reduced in M3 treated pups. Analogously, cardiac IL-6 and IL-1β (e, f) mRNA and (g, h) protein were elevated in vehicle treated pups as opposed to M3 treated septic neonates. Data are expressed as means ± SE (sham = 6, vehicle = 6, and M3 = 7 pups). Multiple groups were compared by one-way ANOVA and Tukey method (*p < 0.05 vs. sham; #p < 0.05 vs. Vehicle)

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