Fig. 2From: Expediting rare disease diagnosis: a call to bridge the gap between clinical and functional genomicsPooled CRISPR screening of genetic variants. a Design of an sgRNA library for screening genetic variants. b Representative data from a proliferation-based pooled CRISPR screen targeting putative noncoding regulatory elements. A selection of sgRNAs targeting common genomic sites have been labeled. c Frequency of clinical presentations in our undiagnosed patient population. d Schematic of pooled CRISPR differentiation screensBack to article page