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Fig. 3 | Molecular Medicine

Fig. 3

From: microRNA-199a-5p regulates epithelial-to-mesenchymal transition in diabetic cataract by targeting SP1 gene

Fig. 3

MiR-199a repressed EMT through SP1 in hyperglycemic LECs. a, b SP1 mRNA and protein expression were significantly decreased by SP1 siRNA transfection (n = 6). c–f After miR-199a mimic transfection, the protein expression of alpha-SMA, vimentin and FSP-1 was downregulated compared with NC mimic in HG condition, while the E-cadherin was upregulated. When SP1 siRNA was transfected, alpha-SMA, vimentin and FSP-1expression decreased while E-cadherin expression increased (n = 6). SP1 specific protein, HG high glucose, LECs lens epithelial cells. *P < 0.05

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