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Table 2 Summary of findings from detection of placental aneuploidy

From: Genomic imbalances in the placenta are associated with poor fetal growth

Study group (N)

Balanced (M:F)

Unbalanced (M:F)

CGH/MLPA result

Inferred karyotype

CPM

Control (173)

171 (86:85)

2 (1:1)

Gain of X

47, XXXa

No

del(X/Yq)

46,XY,del(Yqter)

Unk

SGA (101)

89 (39:50)

12 (4:8)

Gain of 7

47,XX,+7/46,XXa

Yes

Gain of 7

47,XY,+7/46,XYa

Yes

Gain of 2

47,XX,+2/46,XXa

Yes

Gain of 13

47,XX,+13/46,XXa

Yes

dup(7q),del(Xp)

46,XX,der(X) t(X;7)(p22.2;q21.2)/46,XX

Yes

del(4q),dup(4p)

46,XY, der(4)del(4)(q34.2), dup(4)(p16.3p15.31)/46,XY

Yes

Gain of 10, Gain of X

48,XXX,+10/47,XXX

Yesb

N/A

47,XY,+2/46,XY

Unk

N/A

46,XX,+i(15q)/46,XX

Unk

N/A

47,XX, + 16/46,XX

Yes

N/A

47,XX,+16/46,XX

Yes

N/A

47,XY,+16/46,XY

Yes

  1. CGH comparative genomic hybridization, MLPA multiplexed ligation-dependent probe amplification, CPM confined placental mosaicism, Unk. unknown/unable to confirm, N/A not available (cases were only screened by microarray)
  2. aCases published in Robinson et al. (2010)
  3. bConstitutional trisomy X, CPM of trisomy 10