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Table 3 Summary of load of CNVs in control and SGA placentas

From: Genomic imbalances in the placenta are associated with poor fetal growth

  Vancouver cohort Toronto cohort
  Control (N = 24) SGAa (N = 28) Control (N = 37) SGA (N = 25)
N CNVs 17 (11–25) 16 (9–27) 35 (20–57) 32 (22–52)
 Gains 7 (1–11) 7 (1–14) 17 (9–38) 15 (8–36)
 Losses 10 (4–20) 9 (3–17) 18 (9–33) 17 (10–29)
N rare CNVs 4 (1–10) 4 (2–10) 7 (1–29) 6 (1–19)
 Gains 1 (0–6) 2 (0–6) 4 (0–22) 3 (0–16)
 Losses 3 (0–7) 3 (0–9) 3 (0–12) 3 (0–6)
Cumul. size (Mb) 1.22 (0.44–3.43) 1.59 (0.57–5.12) 3.20 (1.25–7.86) 3.17 (1.63–5.80)
 Gains 0.57 (0.03–1.32) 0.86 (0.03–2.85) 2.36 (1.06–6.97) 2.05 (0.97–5.11)
 Losses 0.65 (0.06–2.92) 0.72 (0.11–3.45) 0.84 (0.18–2.33) 1.12 (0.36–4.19)
Cumul. size rare (kb) 219 (10–902) 327 (74–864)* 893 (38–3652) 825 (19–3329)
 Gains 100 (0–781) 197 (0–819) 678 (0–3460) 516 (0–2937)
 Losses 119 (0–485) 130 (0–517) 1570 (0–5776) 1373 (0–4516)
  1. Cumul. cumulative
  2. *p < 0.05, Mann–Whitney U-test. All values reported as mean (range)
  3. aExcludes outlier PM324