Skip to main content
Fig. 1 | Molecular Medicine

Fig. 1

From: Aerobic exercise improves VCI through circRIMS2/miR-186/BDNF-mediated neuronal apoptosis

Fig. 1

Expression of circRIMS2 and BDNF protein in the serum of VCI patients. Fasting venous blood from healthy individuals (n = 20) and VCI patients (n = 20) were collected and centrifuged to obtain serum. a CircRNA microarray analysis and qRT-PCR were used to detect the expression level of circRIMS2 in serum. b qRT-PCR detected the expression level of miR-186. c qRT-PCR detected the mRNA expression level of BDNF, and ELISA detected the BDNF protein content in serum. d Repeated ligation of bilateral common carotid arteries (CCA) caused ischemia–reperfusion injury (2VO) to establish a VCI mouse model and the mice were divided into three groups (n = 6 per group): sham, 2VO, 2VO + aerobic exercise (EX), and qRT-PCR detected the expression of circ-RNAs. *P < 0.05 versus the Healthy group or sham group; **P < 0.01 versus the 2VO group

Back to article page
\