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Fig. 4 | Molecular Medicine

Fig. 4

From: Inhibition of mitochondrial carrier homolog 2 (MTCH2) suppresses tumor invasion and enhances sensitivity to temozolomide in malignant glioma

Fig. 4

MTCH2 knockdown impairs the migration of glioma cells in vitro. a, b Representative images of wound healing assays showing that MTCH2 knockdown inhibits the migration of A172 cells (N = 4). The migration of cells into the wound was assessed at 0, 24, 48 and 72 h. Scale bar, 200 μm. c Images and quantifications showing that MTCH2 knockdown reduces the rate of migration of U87 MG cells by Transwell migration assays. d Immunostaining images showing the reduced F-actin fibers by MTCH2 knockdown in A172 cells. Scale bar, 10 μm. e, f Western blots and quantifications showing that MTCH2 knockdown alters cellular signalings relative to cytoskeleton dynamics

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Molecular Medicine

ISSN: 1528-3658