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Table 3 Association between CASC16 polymorphisms and breast cancer risk

From: The association of CASC16 variants with breast Cancer risk in a northwest Chinese female population

SNP ID

Model

Genotype

Case

N (%)

Control

N (%)

OR (95% CI)

pa

rs3803662

 

Codominant

A/A

318 (46.70)

310 (45.66)

1

 

A/G

308 (45.23)

292 (43.00)

1.03 (0.82–1.29)

0.805

G/G

55 (8.08)

77 (11.34)

0.70 (0.48–1.02)

0.061

Dominant

A/A

318 (46.70)

310 (45.66)

1

 

A/G-G/G

363 (53.30)

369 (54.34)

0.96 (0.77–1.18)

0.700

Recessive

A/A-A/G

626 (91.92)

602 (88.66)

1

 

G/G

55 (8.08)

77 (11.34)

0.69 (0.48–0.99)

0.042

Log-additive

0.90 (0.77–1.06)

0.223

rs4784227

 

Codominant

C/C

353 (52.30)

394 (58.37)

1

 

T/C

270 (40.00)

240 (35.56)

1.26 (1.00–1.57)

0.048

T/T

52 (7.70)

41 (6.07)

1.42 (0.92–2.18)

0.117

Dominant

C/C

353 (52.30)

394 (58.37)

1

 

T/C-T/T

322 (47.70)

281 (41.63)

1.28 (1.03–1.59)

0.025

Recessive

C/C-T/C

623 (92.30)

634 (93.93)

1

 

T/T

52 (7.70)

41 (6.07)

1.29 (0.84–1.97)

0.239

Log-additive

1.22 (1.03–1.45)

0.023

rs45544231

 

Codominant

G/G

445 (65.35)

446 (65.59)

1

 

G/C

204 (29.96)

205 (30.15)

0.99 (0.79–1.26)

0.980

C/C

32 (4.70)

29 (4.26)

1.11 (0.66–1.86)

0.707

Dominant

G/G

445 (65.35)

446 (65.59)

1

 

G/C-C/C

236 (34.65)

234 (34.41)

1.01 (0.81–1.26)

0.928

Recessive

G/G-G/C

649 (95.30)

651 (95.74)

1

 

C/C

32 (4.70)

29 (4.26)

1.11 (0.66–1.85)

0.701

Log-additive

1.02 (0.85–1.23)

0.831

rs12922061

 

Codominant

C/C

348 (51.10)

381 (56.03)

1

 

C/T

278 (40.82)

262 (38.53)

1.16 (0.93–1.45)

0.187

T/T

55 (8.08)

37 (5.44)

1.63 (1.05–2.53)

0.030

Dominant

C/C

348 (51.10)

381 (56.03)

1

 

C/T-T/T

333 (48.90)

299 (43.97)

1.22 (0.99–1.51)

0.068

Recessive

C/C-C/T

626 (91.92)

643 (94.56)

1

 

T/T

55 (8.08)

37 (5.44)

1.53 (0.99–2.35)

0.054

Log-additive

1.22 (1.03–1.45)

0.025

rs3112612

 

Codominant

A/A

444 (65.29)

446 (65.59)

1

 

A/G

204 (30.00)

203 (29.85)

1.01 (0.80–1.28)

0.938

G/G

32 (4.71)

31 (4.56)

1.04 (0.62–1.73)

0.891

Dominant

A/A

444 (65.29)

446 (65.59)

1

 

A/G-G/G

236 (34.71)

234 (34.41)

1.01 (0.81–1.27)

0.911

Recessive

A/A-A/G

648 (95.29)

649 (95.44)

1

 

G/G

32 (4.71)

31 (4.56)

1.03 (0.62–1.72)

0.899

Log-additive

1.01 (0.84–1.22)

0.889

  1. CI confidence interval, OR odds ratio, SNP single nucleotide polymorphism
  2. ap-values were calculated by unconditional logistic regression analysis with adjustment for age
  3. pa < 0.05 indicates statistical significance
  4. Highlighted in bold indicates the significant association between SNPs and breast cancer risk