Table 4 The relationship of CASC16 polymorphisms with breast cancer according to the stratification analysis by age
From: The association of CASC16 variants with breast Cancer risk in a northwest Chinese female population
SNP | Model | Genotype | > 50 years | ≤ 50 years | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
Case | Control | OR (95% CI) | p | Case | Control | OR (95% CI) | p | |||
rs3803662 | Allele | A | 486 (70.43%) | 464 (67.64%) | 1 | 458 (68.15%) | 448 (66.67%) | 1 | ||
G | 204 (29.57%) | 222 (32.36%) | 0.88 (0.70–1.10) | 0.262 | 214(31.85%) | 224(33.33%) | 0.93 (0.74–1.17) | 0.561 | ||
Codominant | A/A | 169 (48.99%) | 151 (44.02%) | 1 | 149 (44.34%) | 159 (47.32%) | 1 | |||
A/G | 148 (42.90%) | 162 (47.23%) | 0.82 (0.60–1.12) | 0.202 | 160 (47.62%) | 130 (38.69%) | 1.31 (0.95–1.81) | 0.097 | ||
G/G | 28 (8.12%) | 30 (8.75%) | 0.83 (0.48–1.46) | 0.526 | 27 (8.04%) | 47 (13.99%) | 0.61 (0.36–1.03) | 0.063 | ||
Dominant | A/A | 169 (48.99%) | 151 (44.02%) | 1 | 149 (44.34%) | 159 (47.32%) | 1 | |||
A/G-G/G | 176 (51.01%) | 192 (55.98%) | 0.82 (0.61–1.11) | 0.191 | 187 (55.65%) | 177 (52.68%) | 1.13 (0.83–1.53) | 0.443 | ||
Recessive | A/A-A/G | 317 (91.88%) | 313 (91.25%) | 1 | 309 (91.96%) | 289 (86.01%) | 1 | |||
G/G | 28(8.12%) | 30(8.75%) | 0.92 (0.54–1.58) | 0.768 | 27 (8.04%) | 47 (13.99%) | 0.53 (0.32–0.88) | 0.014 | ||
Log-additive | – | – | – | 0.87 (0.69–1.10) | 0.249 | – | – | 0.93 (0.74–1.17) | 0.553 | |
rs4784227 | Allele | C | 489 (71.28%) | 531 (77.63%) | 1 | 487 (73.34%) | 497 (74.62%) | 1 | ||
T | 197 (28.72%) | 153 (22.37%) | 1.34 (1.10–1.79) | 0.007 | 177 (26.66%) | 169 (25.38%) | 1.07 (0.84–1.37) | 0.594 | ||
Codominant | C/C | 171 (49.85%) | 205 (59.94%) | 1 | 182 (54.82%) | 189 (56.76%) | 1 | |||
T/C | 147 (42.86%) | 121 (35.38%) | 1.46 (1.06–1.99) | 0.019 | 123 (37.05%) | 119 (35.74%) | 1.07 (0.78–1.49) | 0.665 | ||
T/T | 25 (7.29%) | 16 (4.68%) | 1.88 (0.97–3.64) | 0.061 | 27 (8.13%) | 25 (7.51%) | 1.13 (0.63–2.03) | 0.678 | ||
Dominant | C/C | 171 (49.85%) | 205 (59.94%) | 1 | 182 (54.82%) | 189 (56.76%) | 1 | |||
T/C-T/T | 172 (50.14) | 137 (40.06%) | 1.51 (1.11–2.04) | 0.008 | 150 (45.18%) | 144 (43.24%) | 1.08 (0.80–1.47) | 0.606 | ||
Recessive | C/C-T/C | 318 (92.71%) | 326 (95.32%) | 1 | 305 (91.87%) | 308 (92.49%) | 1 | |||
T/T | 25 (7.29%) | 16 (4.68%) | 1.61 (0.84–3.07) | 0.151 | 27 (8.13%) | 25 (7.51%) | 1.10 (0.62–1.94) | 0.743 | ||
Log-additive | – | – | – | 1.42 (1.10–1.82) | 0.006 | – | – | 1.07 (0.84–1.36) | 0.589 | |
rs45544231 | Allele | G | 569 (82.46%) | 563 (81.83%) | 1 | 525 (78.13%) | 534 (79.46%) | 1 | ||
C | 121 (17.54%) | 125 (18.17%) | 0.96 (0.73–1.26) | 0.759 | 147 (21.88%) | 138 (20.54%) | 1.08 (0.83–1.41) | 0.548 | ||
Codominant | G/G | 239 (69.27%) | 230 (66.86%) | 1 | 206 (61.31%) | 216 (64.29%) | 1 | |||
G/C | 91 (26.38%) | 103 (29.94%) | 0.85 (0.61–1.19) | 0.341 | 113 (33.63%) | 102 (30.36%) | 1.16 (0.83–1.61) | 0.377 | ||
C/C | 15 (4.35%) | 11 (3.20%) | 1.31 (0.59–2.92) | 0.504 | 17 (5.06%) | 18 (5.36%) | 0.98 (0.49–1.96) | 0.964 | ||
Dominant | G/G | 239 (69.27%) | 230 (66.86%) | 1 | 206 (61.31%) | 216 (64.29%) | 1 | |||
G/C-C/C | 106 (30.72%) | 114 (33.14%) | 0.89 (0.65–1.23) | 0.496 | 13 (38.69%) | 120 (35.71%) | 1.13 (0.83–1.55) | 0.433 | ||
Recessive | G/G-G/C | 330 (95.65%) | 333 (96.80%) | 1 | 31 (94.94%) | 318 (94.64%) | 1 | |||
C/C | 15 (4.35%) | 11 (3.20%) | 1.34 (0.62–3.04) | 0.429 | 17 (5.06%) | 18 (5.36%) | 0.94 (0.47–1.85) | 0.849 | ||
Log-additive | – | – | – | 0.96 (0.73–1.26) | 0.763 | – | – | 1.08 (0.83–1.39) | 0.568 | |
rs12922061 | Allele | C | 485 (70.29%) | 525 (76.31%) | 1 | 48 (72.77%) | 499 (74.26%) | 1 | ||
T | 205 (29.71%) | 163 (23.69%) | 1.36 (1.07–1.73) | 0.012 | 18 (27.23%) | 173 (25.74%) | 1.08 (0.85–1.38) | 0.537 | ||
Codominant | C/C | 171(49.57%) | 200 (58.14%) | 1 | 17 (52.68%) | 181 (53.87%) | 1 | |||
C/T | 143 (41.45%) | 125 (36.34%) | 1.34 (0.98–1.83) | 0.070 | 135(40.18%) | 137 (40.77%) | 1.01 (0.74–1.38) | 0.953 | ||
T/T | 31 (8.99%) | 19 (5.52%) | 1.91 (1.04–3.51) | 0.036 | 24 (7.14%) | 18 (5.36%) | 1.37 (0.72–2.61) | 0.340 | ||
Dominant | C/C | 171 (49.57%) | 200 (58.14%) | 1 | 177 (52.68%) | 181 (53.87%) | 1 | |||
C/T-T/T | 174 (50.43%) | 144 (41.86%) | 1.41 (1.05–1.91) | 0.024 | 159 (47.32%) | 155 (46.13%) | 1.05 (0.78–1.42) | 0.747 | ||
Recessive | C/C-C/T | 314 (91.01%) | 325 (94.48%) | 1 | 312 (92.86%) | 318 (94.64%) | 1 | |||
T/T | 31 (8.99%) | 19 (5.52%) | 1.69 (0.94–3.06) | 0.082 | 24 (7.14%) | 18 (5.36%) | 1.36 (0.73–2.56) | 0.335 | ||
Log-additive | – | – | – | 1.36 (1.07–1.73) | 0.012 | – | – | 1.09 (0.85–1.39) | 0.518 | |
rs3112612 | Allele | A | 569 (82.46%) | 562(81.69%) | 1 | 523 (78.06%) | 533 (79.32%) | 1 | ||
G | 121(17.54%) | 126(18.31%) | 0.95 (0.72–1.25) | 0.707 | 147 (21.94%) | 139 (20.68%) | 1.08 (0.83–1.40) | 0.574 | ||
Codominant | A/A | 239 (69.28%) | 230 (66.86%) | 1 | 205 (61.19%) | 216 (64.29%) | 1 | |||
A/G | 91 (26.38%) | 102 (29.65%) | 0.86 (0.61–1.20) | 0.372 | 113 (33.73%) | 101 (30.06%) | 1.18 (0.85–1.64) | 0.331 | ||
G/G | 15 (4.35%) | 12 (3.49%) | 1.20 (0.55–2.63) | 0.641 | 17 (5.07%) | 19 (5.65%) | 0.94 (0.47–1.85) | 0.848 | ||
Dominant | A/A | 239 (69.28%) | 230 (66.86%) | 1 | 205 (61.19%) | 216 (64.29%) | 1 | |||
A/G-G/G | 106 (30.72%) | 114 (33.14%) | 0.89 (0.65–1.23) | 0.496 | 130 (38.81%) | 120 (35.71%) | 1.14 (0.83–1.56) | 0.415 | ||
Recessive | A/A-A/G | 330 (95.65%) | 332 (96.51%) | 1 | 318 (94.93%) | 317 (94.35%) | 1 | |||
G/G | 15 (4.35%) | 12 (3.49%) | 1.26 (0.58–2.73) | 0.560 | 17 (5.07%) | 19 (5.65%) | 0.88 (0.45–1.74) | 0.722 | ||
Log-additive | – | – | – | 0.95 (0.73–1.24) | 0.713 | – | – | 1.07 (0.83–1.38) | 0.596 | |