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Table 5 Correlations between CASC16 polymorphisms and clinical characteristics of patients with breast cancer (adjusted by age)

From: The association of CASC16 variants with breast Cancer risk in a northwest Chinese female population

SNPGenotypeClinical stageTumor size (cm)LN metastasis
III,IV/I,IIOR (95% CI)p-value> 2 / ≤2OR (95% CI)p-valuePositive/NegativeOR (95% CI)p-value
rs3803662A213/4471 568/1911 454/4501 
G87/1950.94 (0.69–1.27)0.668250/870.97 (0.72–1.30)0.819192/2120.90 (0.71–1.14)0.368
AA71/1511 191/671 153/1491 
GA71/1451.02 (0.68–1.53)0.917186/571.13 (0.0.75–1.71)0.546148/1520.95 (0.69–1.31)0.744
GG8/250.66 (0.28–1.53)0.33132/150.73 (0.37–1.44)0.36722/300.71 (0.39–1.30)0.270
GA + GG79/1700.97 (0.66–1.43)0.869218/721.05 (0.71–1.55)0.803170/1820.91 (0.67–1.24)0.547
rs4784227C206/4791 589/2001 447/4911 
T94/1631.34 (0.99–1.81)0.056219/760.98 (0.72–1.33)0.889197/1611.34 (1.05–1.72)0.018
CC73/1771 220/691 155/1851 
TC60/1251.19 (0.79–1.81)0.400149/620.77 (0.51–1.15)0.194137/1211.35 (0.98–1.87)0.069
TT17/192.19 (1.08–4.46)0.03135/71.59 (0.67–3.73)0.29230/201.79 (0.98–3.28)0.059
TC + TT77/1441.33 (0.90–1.96)0.155184/690.85 (0.58–1.25)0.410167/1411.41 (1.04–1.93)0.028
rs45544231G245/5321 661/2091 526/5221 
C55/1101.09 (0.76–1.55)0.652157/690.72 (0.52–0.99)0.045120/1400.85 (0.65–1.12)0.244
GG100/2231 267/861 215/2111 
CG45/861.14 (0.74–1.76)0.549127/371.09 (0.70–1.70)0.69396/1000.94 (0.67–1.32)0.726
CC5/1200.89 (0.30–2.61)0.83315/160.29 (0.14–0.61)0.00112/200.59 (0.28–1.23)0.160
CG + CC50/2061.11 (0.73–1.69)0.621142/530.85 (0.57–1.27)0.424108/1200.88 (0.64–1.22)0.450
rs12922061C208/4701 583/2031 444/4901 
T92/1721.21 (0.89–1.63)0.217235/751.09 (0.80–1.48)0.576202/1721.30 (1.02–1.65)0.034
CC73/1721 212/721 152/1811 
TC62/1261.18 (0.78–1.78)0.424159/590.93 (0.62–1.34)0.709140/1281.30 (0.94–1.80)0.108
TT15/231.58 (0.78–3.20)0.20938/81.64 (0.73–3.68)0.23231/221.68 (0.93–3.02)0.084
TC + TT77/1491.24 (0.84–1.84)0.275197/671.24 (0.84–1.84)0.955171/1501.34 (0.99–1.85)0.051
rs3112612A245/5321 661/2071 526/5201 
G55/1101.09 (0.76–1.55)0.652157/690.71 (0.52–0.98)0.039120/1400.85 (0.65–1.11)0.233
AA100/2231 267/851 215/2101 
GA45/861.14 (0.74–1.76)0.549127/371.08 (0.69–1.68)0.73996/1000.94 (0.67–1.31)0.702
GG5/120.89 (0.30–2.61)0.83315/160.28 (0.14–0.60)0.00112/200.58 (0.28–1.23)0.155
GA + GG50/981.11 (0.73–1.69)0.621142/530.84 (0.56–1.25)0.386108/1200.88 (0.64–1.21)0.429
  1. p values were calculated by unconditional logistic regression adjusted by age; p < 0.05 indicates statistical significance
  2. LN lymph node
  3. Highlighted in bold indicates the significant association between SNPs and breast cancer risk