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Table 6 The associations between CASC16 polymorphisms and BMI of breast cancer patients (adjusted by age and BMI)

From: The association of CASC16 variants with breast Cancer risk in a northwest Chinese female population

SNP

Genotype

> 24 kg/m2

≤ 24 kg/m2

Case/Control

OR (95% CI)

p

Case/Control

OR (95% CI)

p

rs3803662

A

231/144

1

 

462/313

1

 

G

105/84

0.78 (0.55–1.11)

0.167

204/165

0.84 (0.65–1.08)

0.165

AA

76/47

1

 

159/101

1

 

GA

79/50

0.97 (0.58–1.61)

0.899

144/111

0.83 (0.59–1.19)

0.313

GG

13/17

0.46 (0.20–1.04)

0.063

30/27

0.73 (0.41–1.30)

0.287

GA + GG

92/67

0.84(0.52–1.36)

0.481

174/138

0.81 (0.58–1.14)

0.230

rs4784227

C

231/174

1

 

476/361

1

 

T

103/52

1.49 (1.01–2.20)

0.042

180/117

1.17 (0.89–1.53)

0.263

CC

77/65

1

 

172/135

1

 

TC

77/44

1.49 (0.91–2.46)

0.115

132/91

1.13 (0.79–1.60)

0.503

TT

13/4

2.64 (0.82–8.54)

0.104

24/13

1.45 (0.71–2.95)

0.308

TC + TT

90/48

1.59(0.98–2.58)

0.059

156/104

1.17 (0.83–1.63)

0.366

rs45544231

G

271/181

1

 

534/383

1

 

C

65/47

0.92 (0.61–1.41)

0.711

132/97

0.98 (0.73–1.31)

0.871

GG

111/72

1

 

217/154

1

 

CG

49/37

0.83 (0.49–1.40)

0.481

100/75

0.96 (0.67–1.38)

0.817

CC

8/5

0.98 (0.31–3.15)

0.979

16/11

1.07 (0.48–2.38)

0.869

CG + CC

57/42

0.85 (0.51–1.40)

0.516

116/86

0.97 (0.69–1.34)

0.873

rs12922061

C

229/175

1

 

478/353

1

 

T

107/53

1.54 (1.05–2.26)

0.026

188/127

1.09 (0.84–1.42)

0.508

CC

78/62

1

 

166/129

1

 

TC

73/51

1.15 (0.70–1.88)

0.581

146/95

1.20 (0.85–1.70)

0.306

TT

17/1

13.41 (1.74–103.6)

0.013

21/16

1.01 (0.51–2.02)

0.968

TC + TT

90/52

1.39 (0.86–2.25)

0.178

167/111

1.17 (0.84–1.64)

0.351

rs3112612

A

271/181

1

 

532/382

1

 

G

65/47

0.92 (0.61–1.41)

0.711

132/98

0.97 (0.72–1.30)

0.823

AA

111/72

1

 

216/154

1

 

GA

49/37

0.83 (0.49–1.40)

0.481

100/74

0.97 (0.68–1.40)

0.887

GG

8/5

0.98 (0.31–3.15)

0.979

16/12

0.99 (0.47–2.18)

0.994

GA + GG

57/42

0.85 (0.51–1.40)

0.516

116/86

0.98 (0.69–1.38)

0.896

  1. p values were calculated by unconditional logistic regression adjusted by age and BMI; p < 0.05 indicates statistical significance
  2. Highlighted in bold indicates the significant association between SNPs and breast cancer risk
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Molecular Medicine

ISSN: 1528-3658