|
Clinical parameters
|
OS
|
DFS
|
|---|
|
No.a
|
HR (95% CI)b
|
p
|
No.a
|
HR (95% CI)b
|
p
|
|---|
|
Age
| | |
< 0.001
| | |
0.001
|
|
≤ 60 years
|
67
|
1
| |
67
|
1
| |
|
> 60 years
|
58
|
2.96 (1.63–5.36)
| |
56
|
2.45 (1.42–4.23)
| |
|
Lymph node status
| | |
0.055
| | |
0.118
|
|
N0
|
70
|
1
| |
69
|
1
| |
|
N1/N2/N3
|
55
|
1.74 (0.99–3.07)
| |
54
|
1.53 (0.90–2.59)
| |
|
Tumor size
| | |
0.117
| | |
0.204
|
|
≤ 20 mm
|
33
|
1
| |
33
|
1
| |
|
> 20 mm
|
91
|
1.83 (0.86–3.92)
| |
89
|
1.54 (0.79–2.98)
| |
|
Histological grade
| | |
0.915
| | |
0.600
|
|
II
|
21
|
1
| |
21
|
1
| |
|
III
|
104
|
1.04 (0.49–2.23)
| |
102
|
1.22 (0.58–2.59)
| |
|
KLK12 mRNAc
| | |
0.037
| | |
0.010
|
|
Negative
|
61
|
1
| |
59
|
1
| |
|
Positive
|
54
|
1.91 (1.04–3.50)
| |
54
|
2.12 (1.19–3.78)
| |
|
KLK12 mRNA posd
| | |
0.047
| | |
0.051
|
|
Low
|
16
|
1
| |
16
|
1
| |
|
High
|
38
|
2.98 (1.02–8.74)
| |
38
|
2.64 (1.00–6.96)
| |
- Significant p-values (p ≤ 0.05) are indicated in bold, trends towards significance (p ≤ 0.06) in italics
- Due to missing values, numbers do not always add up to n = 125 (OS) and n = 123 (DFS), when the whole cohort is analyzed
- a Number of patients
- bHR Hazard ratio (CI Confidence interval) of univariate Cox regression analysis
- c Dichotomized into positive and negative expression
- d Positive KLK12 mRNA values were dichotomized into low and high expression by the 30th percentile
