Table 1 Different types of mTORC2 targeted drugs

ATP-competitive mTOR inhibitor

CZ415

Head and neck squamous cell carcinoma (HNSCC), papillary thyroid carcinoma

(Xie et al. 2018; Li et al. 2018)

Torin2

Adult T-cell leukemia/lymphoma, anaplastic thyroid cancer

(Watanabe et al. 2016; Sadowski et al. 2015)

MLN0128

(INK128)

Intrahepatic cholangiocarcinoma

Neuroblastoma, breast cancer, osteosarcoma

(Zhang et al. 2017; Zhang et al. 2015; Liu et al. 2016)

PP242

Glioblastoma, ovarian cancer

(Mecca et al. 2018; Kawata et al. 2018; Musa et al. 2016)

AZD8055

Adult T-cell leukemia (ATL), hepatocellular carcinoma, colon cancer, neuroblastoma

(Kawata et al. 2018; Chen et al. 2018; Xu et al. 2018)

AZD2014

Diffuse intrinsic pontine glioma (DIPG), gastric cancer, anaplastic thyroid carcinoma (ATC), ovarian cancer

(Kim et al. 2017a; Milosevic et al. 2018; Wong Te Fong et al. 2017; Flannery et al. 2018)

PI3K/mTOR inhibitor

Dactolisib

(BEZ235)

Colon cancer, glioblastomas, breast cancer

(Yu et al. 2016; Shi et al. 2018; Torki et al. 2017)

GSK1059615

Head and neck squamous cell carcinoma (HNSCC)

(Xie et al. 2017a)

LY3023414

Esophageal Adenocarcinoma

(Zaidi et al. 2017)

voxtalisib

(SAR245409, XL765)

endometrial carcinoma

(Yu et al. 2014; Inaba et al. 2015)

PQR309

brain tumor or CNS metastasis

(Beaufils et al. 2017)

gedatolisib (PKI-587, PF05212384)

breast, colon, lung, and glioma carcinoma

(Venkatesan et al. 2010)

omipalisib (GSK2126458)

breast carcinoma

(Knight et al. 2010)

mTORC1/2 dual inhibitor

CC-223

Hepatocellular carcinoma, colorectal cancer, head and neck squamous cell carcinoma (HNSCC)

(Xie et al. 2017b; Wang et al. 2018a)

Ku0063794

Hepatocellular carcinoma

(Kim et al. 2017b)

OSI027

Pancreatic cancer, colon cancer

(Chen et al. 2015; Bhagwat et al. 2011; Zhi et al. 2015)

RES-529 (Palomid 529)

Osteosarcoma, angiogenesis and vascular permeability, prostate cancer

(Hu et al. 2018; Xue et al. 2008; Gravina et al. 2011)

WYE-687

Renal carcinoma, acute myeloid leukemia (AML)

(Pan et al. 2017; Cheng et al. 2016)

WYE-354

Colon cancer, gallbladder cancer

(Wang et al. 2016; Weber et al. 2015)