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Fig. 2 | Molecular Medicine

Fig. 2

From: Elevated MST1 leads to apoptosis via depletion of YAP1 in cardiomyocytes exposed to high glucose

Fig. 2

Effects of mammalian sterile 20-like kinase 1 (MST1) on high glucose (HG)-induced cardiomyocyte apoptosis. a Western blotting confirmation of MST1 knockdown by an MST1-specific or control small interfering RNA. b Hoechst 33342 staining assay showing restrained HG-induced cell apoptosis under knockdown of MST1. c Apoptosis rates were calculated based on ≥ 100 cells and analyzed after HG treatment; *p < 0.05 and **p < 0.01 versus the untreated group; #p < 0.05 and ##p < 0.01 versus the HG-treated group. d Western blotting confirmation of ectopic overexpression of MST1 after transfection of H9C2 cells. e Hoechst 33342 stain apoptosis assay showing the effect of MST1 overexpression on apoptosis in H9C2 cells; (F) Apoptosis rates were calculated based on ≥ 100 cells and analyzed after MST1 transfection; *p < 0.05 and **p < 0.01 versus the non-transfected group

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