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Fig. 3 | Molecular Medicine

Fig. 3

From: Elevated MST1 leads to apoptosis via depletion of YAP1 in cardiomyocytes exposed to high glucose

Fig. 3

Association between knockdown of yes-associated protein 1 (YAP1) and mammalian sterile 20-like kinase 1 (MST1)-mediated cardiomyocyte apoptosis. a Immunohistochemical staining showed of YAP1 in the myocardium of normal and diabetes-exposed embryos (n = 3). Scale bar: 50 µm. b Western blotting with the indicated antibodies confirming the decrease in YAP1 protein in fetal hearts at E15.5 from the normal and diabetic groups (n = 8 each). β-actin was used as an internal reference control. c Western blotting of YAP1 protein in cardiomyocytes after 2 days of high glucose (HG) treatment; experiments were replicated 3 times. d The mRNA expression of YAP1 in cardiomyocytes after HG treatment; data are based on three independent experiments

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