Fig. 5
From: Elevated MST1 leads to apoptosis via depletion of YAP1 in cardiomyocytes exposed to high glucose
Mediation of yes-associated protein 1 (YAP1) phosphorylation by mammalian sterile 20-like kinase 1 (MST1) in response to high glucose (HG) in cardiomyocytes. Western blotting-estimates of: phosphorylation levels of a YAP1 and b large tumor suppressor kinase 1 and 2 (LATS1/2) at Thr1079 and 1041 in H9C2 cells after transfection with the MST1 overexpression plasmid. c Knockdown of MST1 suppressed the HG-induced increased phosphorylation of LATS1/2 at Thr1079 and 1041; d LATS1/2 protein and phosphorylation levels in fetal hearts from the diabetic and normal groups (n = 8 each)