TY - JOUR AU - Cao, Zhongliu AU - Wu, Yanfeng AU - Yu, Lingling AU - Zou, Lingfeng AU - Yang, Liu AU - Lin, Sijian AU - Wang, Jue AU - Yuan, Zhen AU - Dai, Jianghua PY - 2021 DA - 2021/02/26 TI - Exosomal miR-335 derived from mature dendritic cells enhanced mesenchymal stem cell-mediated bone regeneration of bone defects in athymic rats JO - Molecular Medicine SP - 20 VL - 27 IS - 1 AB - Transplantation of bone marrow-derived mesenchymal stem cells (BM-MSCs) embedded in a bio-compatible matrix has been demonstrated as a promising strategy for the treatment of bone defects. This study was designed to explore the effect and mechanism of exosomes derived from mature dendritic cells (mDC-Exo) on the BM-MSCs-mediated bone regeneration using the matrix support in an athymic rat model of femoral bone defect. SN - 1528-3658 UR - https://doi.org/10.1186/s10020-021-00268-5 DO - 10.1186/s10020-021-00268-5 ID - Cao2021 ER -