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Fig. 5 | Molecular Medicine

Fig. 5

From: Exosomal miR-335 derived from mature dendritic cells enhanced mesenchymal stem cell-mediated bone regeneration of bone defects in athymic rats

Fig. 5

mDC-Exo enhanced BM-MSCs-mediated bone regeneration by transferring miR-335. Rats were randomly divided into five groups: Matrix, Matrix + BM-MSCs, Matrix + BM-MSCs + mDC-Exo, Matrix + BM-MSCs + mDC-Exo-NC, and Matrix + BM-MSCs + mDC-Exo-miR-335I. a Bone regeneration was monitored via micro-CT scanning at 4, 8 and 12 weeks post-surgery. b Quantification of new bone volume from micro-CT scanning. c Representative H&E staining showing bone defect repair of posterior limbs of rats. d Quantification of new bone area from H&E staining. The protein levels of e ALP, Runx2, and f, g LAST1 in the bone examined by western blot. *P < 0.05, **P < 0.01, vs. Matrix; #P < 0.05, ##P < 0.01, vs. Matrix + BM-MSCs; $P < 0.05, $$P < 0.01, vs. Matrix + BM-MSCs + mDC-Exo-NC

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