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Fig. 1 | Molecular Medicine

Fig. 1

From: Discovery of vanoxerine dihydrochloride as a CDK2/4/6 triple-inhibitor for the treatment of human hepatocellular carcinoma

Fig. 1

The effect of nine candidate CDK4/6 inhibitors on the viability of QGY7703 and Huh7 cells. The effect of nine candidate compounds on the cell viability of a QGY7703 and b Huh7 cell lines as determined by MTT assay. Vanoxerine dihydrochloride exhibited the highest cyto-toxicity in both cell lines. Vanoxerine dihydrochloride reduced cell viability dose- and time-dependently in c QGY7703 and d Huh7 cell lines. IC50 values was calculated to be 3.79 μM for QGY7703 and 4.04 μM for Huh7. *p < 0.05, significantly different from the control PBS treatment group

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