Skip to main content
Fig. 5 | Molecular Medicine

Fig. 5

From: ELAVL1 is transcriptionally activated by FOXC1 and promotes ferroptosis in myocardial ischemia/reperfusion injury by regulating autophagy

Fig. 5

Knockdown of ELAVL1 suppresses I/R induced ferroptosis and injury via inhibiting autophagy. For inhibition of ELAVL1 or overexpression of Beclin-1, mice were received injection of lenti-si-ELAVL1 or Beclin-1. a Relative mRNA levels of ELAVL1 and Beclin-1 were measured by qRT-PCR. bf Relative protein levels of p62, GPx4, Beclin-1, and LC3 were determined by western blotting. Relative iron level g, LDH activity h and LPO level i were assessed by corresponding assay kits. j Representative TTC staining images of myocardial sections from each group of mice. k Quantifications of infarct size in each group of mice. The results were presented as the mean ± SD. n = 5; *P < 0.05, **P < 0.01, ***P < 0.001

Back to article page
\