Fig. 1
AC-YVAD-CMK improved spatial learning and memory ability and reduced senile plaque deposition of APP/PS1 mice. APP/PS1 mice were intraperitoneally injected with AC-YVAD-CMK or DMSO. WT C57/BL6 mice were served as control. a, b Spatial learning and memory ability of mice were detected by morris water maze. c, d Immunohistochemistry and Thioflavin S staining were performed to examine the senile plaque deposition in the hippocampal tissues (subregions between DG and CA1) of mice. e TUNEL staining was performed to assess apoptosis in hippocampal neurones of mice. The arrows indicated the Aβ1-42. (One-way ANOVA; **P < 0.01 vs. WT group; ##P < 0.01 vs. APP/PS1 group.)