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Fig. 2 | Molecular Medicine

Fig. 2

From: Caspase-1/IL-1β represses membrane transport of GluA1 by inhibiting the interaction between Stargazin and GluA1 in Alzheimer’s disease

Fig. 2

AC-YVAD-CMK promoted membrane transport of GluA1 in APP/PS1 mice. APP/PS1 mice were intraperitoneally injected with AC-YVAD-CMK or DMSO. WT C57/BL6 mice were served as control. a WB was performed to detect the expression of caspase-1 in the hippocampal tissues of mice. b ELISA was performed to assess the levels of IL-1β in the hippocampal tissues of mice. c WB was performed to estimate the expression of GluA1 in the hippocampal tissues of mice. S: surface; I: intracellular. (One-way ANOVA; *P < 0.05, **P < 0.01 vs. WT group; #P < 0.05, ##P < 0.01 vs. APP/PS1 group.)

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Molecular Medicine

ISSN: 1528-3658