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Table 1 Cytokeratin 18 immunostaining in human tumors

From: Diagnostic and prognostic impact of cytokeratin 18 expression in human tumors: a tissue microarray study on 11,952 tumors

 

Entity

On TMA (n)

CK18 immunostaining

Analyzable (n)

Negative (%)

Weak (%)

Moderate (%)

Strong (%)

Positive (%)

Tumors of the skin

Pilomatrixoma

35

28

100.0

0.0

0.0

0.0

0.0

 

Basal cell carcinoma

48

42

100.0

0.0

0.0

0.0

0.0

 

Benign nevus

29

23

100.0

0.0

0.0

0.0

0.0

 

Squamous cell carcinoma of the skin

50

44

93.2

6.8

0.0

0.0

6.8

 

Malignant melanoma

48

43

100.0

0.0

0.0

0.0

0.0

 

Merkel cell carcinoma

46

43

32.6

16.3

23.3

27.9

67.4

Tumors of the head and neck

Squamous cell carcinoma of the larynx

50

43

72.1

25.6

0.0

2.3

27.9

 

Oral squamous cell carcinoma (floor of the mouth)

50

43

93.0

7.0

0.0

0.0

7.0

 

Pleomorphic adenoma of the parotid gland

50

42

23.8

50.0

19.0

7.1

76.2

 

Warthin tumor of the parotid gland

49

47

0.0

40.4

36.2

23.4

100.0

 

Basal cell adenoma of the salivary gland

15

15

6.7

60.0

6.7

26.7

93.3

Tumors of the lung, pleura and thymus

Adenocarcinoma of the lung

200

176

0.0

29.5

28.4

42.0

100.0

 

Squamous cell carcinoma of the lung

77

66

39.4

48.5

7.6

4.5

60.6

 

Small cell carcinoma of the lung

20

16

18.8

12.5

50.0

18.8

81.3

 

Malignant mesothelioma

48

40

12.5

12.5

15.0

60.0

87.5

 

Mesothelioma, other types

28

18

11.1

33.3

16.7

38.9

88.9

 

Mesothelioma, epitheloid

39

26

3.8

11.5

34.6

50.0

96.2

Tumors of the female genital tract

Squamous cell carcinoma of the vagina

48

20

90.0

5.0

0.0

5.0

10.0

 

Squamous cell carcinoma of the vulva

50

33

100.0

0.0

0.0

0.0

0.0

 

Squamous cell carcinoma of the cervix

50

35

88.6

2.9

0.0

8.6

11.4

 

Adenocarcinoma of the cervix uteri

50

38

0.0

13.2

23.7

63.2

100.0

 

Endometrioid endometrial carcinoma

236

212

0.5

14.2

22.2

63.2

99.5

 

Endometrial serous carcinoma

82

53

1.9

15.1

34.0

43.4

92.5

 

Carcinosarcoma of the uterus

48

38

21.1

26.3

34.2

18.4

78.9

 

Endometrial clear cell carcinoma

8

7

0.0

57.1

42.9

0.0

100.0

 

Endometrial carcinoma, low differentiated G3

13

12

33.3

33.3

25.0

8.3

66.7

 

Endometrial stromal sarcoma

12

10

100.0

0.0

0.0

0.0

0.0

 

Endometrioid carcinoma of the ovary

115

86

1.2

4.7

26.7

67.4

98.8

 

Serous carcinoma of the ovary

567

495

0.8

13.7

31.9

53.5

99.2

 

Mucinous carcinoma of the ovary

97

75

0.0

17.3

18.7

64.0

100.0

 

Clear cell carcinoma of the ovary

54

47

8.5

34.0

31.9

25.5

91.5

 

Carcinosarcoma of the ovary

47

41

22.0

14.6

24.4

39.0

78.0

 

Brenner tumor

9

8

62.5

37.5

0.0

0.0

37.5

Tumors of the breast

Invasive breast carcinoma of no special type

1391

1001

3.6

21.8

23.5

50.9

96.2

 

Lobular carcinoma of the breast

294

229

0.4

21.0

26.6

52.0

99.6

 

Medullary carcinoma of the breast

26

22

59.1

18.2

9.1

13.6

40.9

 

Tubular carcinoma of the breast

27

17

0.0

23.5

17.6

58.8

100.0

 

Mucinous carcinoma of the breast

58

35

0.0

11.4

37.1

51.4

100.0

 

Phyllodes tumor of the breast

50

32

0.0

37.5

21.9

40.6

100.0

Tumors of the digestive system

Adenomatous polyp, low-grade dysplasia

50

41

0.0

0.0

0.0

100.0

100.0

 

Adenomatous polyp, high-grade dysplasia

50

44

0.0

0.0

2.3

97.7

100.0

 

Adenocarcinoma of the colon

1932

1750

2.6

2.3

9.9

85.3

97.4

 

Adenocarcinoma of the small intestine

10

5

0.0

0.0

0.0

100.0

100.0

 

Gastric adenocarcinoma, diffuse type

226

161

5.6

32.3

28.6

33.5

94.4

 

Gastric adenocarcinoma, intestinal type

224

156

7.1

23.7

19.2

50.0

92.9

 

Gastric adenocarcinoma, mixed type

62

59

5.1

25.4

22.0

47.5

94.9

 

Adenocarcinoma of the esophagus

133

70

1.4

12.9

7.1

78.6

98.6

 

Squamous cell carcinoma of the esophagus

124

63

68.3

22.2

0.0

9.5

31.7

 

Squamous cell carcinoma of the anal canal

50

33

75.8

15.2

9.1

0.0

24.2

 

Cholangiocarcinoma

130

112

1.8

17.0

29.5

51.8

98.2

 

Hepatocellular carcinoma

50

49

8.2

28.6

20.4

42.9

91.8

 

Ductal adenocarcinoma of the pancreas

612

523

1.0

16.8

25.6

56.6

99.0

 

Pancreatic/Ampullary adenocarcinoma

89

76

5.3

6.6

25.0

63.2

94.7

 

Acinar cell carcinoma of the pancreas

13

12

0.0

0.0

16.7

83.3

100.0

 

Gastrointestinal stromal tumor (GIST)

50

42

97.6

2.4

0.0

0.0

2.4

Tumors of the urinary system

Non-invasive papillary urothelial carcinoma, pTa G2 low grade

177

109

41.3

11.9

23.9

22.9

58.7

 

Non-invasive papillary urothelial carcinoma, pTa G2 high grade

141

100

36.0

20.0

24.0

20.0

64.0

 

Non-invasive papillary urothelial carcinoma, pTa G3

187

144

18.8

27.8

24.3

29.2

81.3

 

Urothelial carcinoma, pT2-4 G3

1164

939

39.7

28.1

14.7

17.5

60.3

 

Small cell neuroendocrine carcinoma of the bladder

18

18

33.3

33.3

11.1

22.2

66.7

 

Sarcomatoid urothelial carcinoma

25

18

66.7

33.3

0.0

0.0

33.3

 

Clear cell renal cell carcinoma

858

722

47.5

31.2

14.3

7.1

52.5

 

Papillary renal cell carcinoma

255

209

2.4

15.3

15.8

66.0

97.1

 

Chromophobe renal cell carcinoma

131

112

0.9

9.8

20.5

68.8

99.1

 

Oncocytoma

177

144

1.4

11.8

16.7

69.4

97.9

 

Clear cell (tubulo) papillary renal cell carcinoma

21

18

27.8

5.6

16.7

50.0

72.2

Tumors of the male genital organs

Adenocarcinoma of the prostate, Gleason 3 + 3

83

82

0.0

1.2

1.2

97.6

100.0

 

Adenocarcinoma of the prostate, Gleason 4 + 4

80

73

0.0

4.1

1.4

94.5

100.0

 

Adenocarcinoma of the prostate, Gleason 5 + 5

85

81

0.0

3.7

11.1

85.2

100.0

 

Adenocarcinoma of the prostate (recurrence)

330

287

6.3

16.0

27.9

49.8

93.7

 

Small cell neuroendocrine carcinoma of the prostate

17

16

25.0

18.8

37.5

18.8

75.0

 

Seminoma

220

204

97.5

2.5

0.0

0.0

2.5

 

Germ cell neoplasia in situ

85

67

64.2

29.9

3.0

3.0

35.8

 

Embryonal carcinoma of the testis

50

46

0.0

23.9

19.6

56.5

100.0

 

Yolk sack tumor

50

42

0.0

38.1

21.4

40.5

100.0

 

Teratoma

50

27

70.4

14.8

0.0

14.8

29.6

Tumors of endocrine organs

Adenoma of the thyroid gland

114

109

0.0

5.5

35.8

58.7

100.0

 

Papillary thyroid carcinoma

392

381

0.3

1.6

14.7

83.5

99.7

 

Follicular thyroid carcinoma

158

150

0.0

2.0

34.0

64.0

100.0

 

Medullary thyroid carcinoma

107

98

1.0

6.1

33.7

59.2

99.0

 

Anaplastic thyroid carcinoma

45

43

41.9

32.6

14.0

11.6

58.1

 

Adrenal cortical adenoma

50

36

91.7

5.6

0.0

2.8

8.3

 

Adrenal cortical carcinoma

26

20

70.0

10.0

0.0

20.0

30.0

 

Phaeochromocytoma

50

42

100.0

0.0

0.0

0.0

0.0

 

Appendix, neuroendocrine tumor (NET)

22

15

0.0

8.3

0.0

91.7

100.0

 

Colorectal, neuroendocrine tumor (NET)

10

10

0.0

0.0

10.0

90.0

100.0

 

Ileum, neuroendocrine tumor (NET)

49

45

0.0

2.2

2.2

95.6

100.0

 

Lung, neuroendocrine tumor (NET)

19

18

0.0

11.8

17.6

70.6

100.0

 

Pancreas, neuroendocrine tumor (NET)

102

79

1.3

5.1

31.6

62.0

98.7

 

Colorectal, neuroendocrine carcinoma (NEC)

11

9

33.3

22.2

22.2

22.2

66.7

 

Gallbladder, neuroendocrine carcinoma (NEC)

4

4

50.0

0.0

25.0

25.0

50.0

 

Pancreas, neuroendocrine carcinoma (NEC)

13

7

28.6

28.6

0.0

42.9

71.4

Tumors of haemotopoetic and lymphoid tissues

Hodgkin Lymphoma

45

39

100.0

0.0

0.0

0.0

0.0

 

Non-Hodgkin Lymphoma

48

41

100.0

0.0

0.0

0.0

0.0

Tumors of soft tissue and bone

Tenosynovial giant cell tumor

45

43

100.0

0.0

0.0

0.0

0.0

 

Granular cell tumor

53

32

100.0

0.0

0.0

0.0

0.0

 

Leiomyoma

50

32

100.0

0.0

0.0

0.0

0.0

 

Angiomyolipoma

91

74

98.6

1.4

0.0

0.0

1.4

 

Angiosarcoma

73

55

87.3

7.3

3.6

1.8

12.7

 

Dermatofibrosarcoma protuberans

21

16

100.0

0.0

0.0

0.0

0.0

 

Ganglioneuroma

14

11

100.0

0.0

0.0

0.0

0.0

 

Kaposi sarcoma

8

5

100.0

0.0

0.0

0.0

0.0

 

Leiomyosarcoma

87

70

100.0

0.0

0.0

0.0

0.0

 

Liposarcoma

132

98

100.0

0.0

0.0

0.0

0.0

 

Malignant peripheral nerve sheath tumor (MPNST)

13

12

100.0

0.0

0.0

0.0

0.0

 

Myofibrosarcoma

26

24

100.0

0.0

0.0

0.0

0.0

 

Neurofibroma

117

103

100.0

0.0

0.0

0.0

0.0

 

Sarcoma, not otherwise specified (NOS)

75

67

94.0

4.5

1.5

0.0

6.0

 

Paraganglioma

41

37

100.0

0.0

0.0

0.0

0.0

 

Primitive neuroectodermal tumor (PNET)

23

13

100.0

0.0

0.0

0.0

0.0

 

Rhabdomyosarcoma

7

6

100.0

0.0

0.0

0.0

0.0

 

Schwannoma

121

93

98.9

0.0

1.1

0.0

1.1

 

Synovial sarcoma

12

10

100.0

0.0

0.0

0.0

0.0

 

Osteosarcoma

43

29

96.6

3.4

0.0

0.0

3.4

 

Chondrosarcoma

39

21

100.0

0.0

0.0

0.0

0.0