Entity | On TMA (n) | CK18 immunostaining | ||||||
---|---|---|---|---|---|---|---|---|
Analyzable (n) | Negative (%) | Weak (%) | Moderate (%) | Strong (%) | Positive (%) | |||
Tumors of the skin | Pilomatrixoma | 35 | 28 | 100.0 | 0.0 | 0.0 | 0.0 | 0.0 |
Basal cell carcinoma | 48 | 42 | 100.0 | 0.0 | 0.0 | 0.0 | 0.0 | |
Benign nevus | 29 | 23 | 100.0 | 0.0 | 0.0 | 0.0 | 0.0 | |
Squamous cell carcinoma of the skin | 50 | 44 | 93.2 | 6.8 | 0.0 | 0.0 | 6.8 | |
Malignant melanoma | 48 | 43 | 100.0 | 0.0 | 0.0 | 0.0 | 0.0 | |
Merkel cell carcinoma | 46 | 43 | 32.6 | 16.3 | 23.3 | 27.9 | 67.4 | |
Tumors of the head and neck | Squamous cell carcinoma of the larynx | 50 | 43 | 72.1 | 25.6 | 0.0 | 2.3 | 27.9 |
Oral squamous cell carcinoma (floor of the mouth) | 50 | 43 | 93.0 | 7.0 | 0.0 | 0.0 | 7.0 | |
Pleomorphic adenoma of the parotid gland | 50 | 42 | 23.8 | 50.0 | 19.0 | 7.1 | 76.2 | |
Warthin tumor of the parotid gland | 49 | 47 | 0.0 | 40.4 | 36.2 | 23.4 | 100.0 | |
Basal cell adenoma of the salivary gland | 15 | 15 | 6.7 | 60.0 | 6.7 | 26.7 | 93.3 | |
Tumors of the lung, pleura and thymus | Adenocarcinoma of the lung | 200 | 176 | 0.0 | 29.5 | 28.4 | 42.0 | 100.0 |
Squamous cell carcinoma of the lung | 77 | 66 | 39.4 | 48.5 | 7.6 | 4.5 | 60.6 | |
Small cell carcinoma of the lung | 20 | 16 | 18.8 | 12.5 | 50.0 | 18.8 | 81.3 | |
Malignant mesothelioma | 48 | 40 | 12.5 | 12.5 | 15.0 | 60.0 | 87.5 | |
Mesothelioma, other types | 28 | 18 | 11.1 | 33.3 | 16.7 | 38.9 | 88.9 | |
Mesothelioma, epitheloid | 39 | 26 | 3.8 | 11.5 | 34.6 | 50.0 | 96.2 | |
Tumors of the female genital tract | Squamous cell carcinoma of the vagina | 48 | 20 | 90.0 | 5.0 | 0.0 | 5.0 | 10.0 |
Squamous cell carcinoma of the vulva | 50 | 33 | 100.0 | 0.0 | 0.0 | 0.0 | 0.0 | |
Squamous cell carcinoma of the cervix | 50 | 35 | 88.6 | 2.9 | 0.0 | 8.6 | 11.4 | |
Adenocarcinoma of the cervix uteri | 50 | 38 | 0.0 | 13.2 | 23.7 | 63.2 | 100.0 | |
Endometrioid endometrial carcinoma | 236 | 212 | 0.5 | 14.2 | 22.2 | 63.2 | 99.5 | |
Endometrial serous carcinoma | 82 | 53 | 1.9 | 15.1 | 34.0 | 43.4 | 92.5 | |
Carcinosarcoma of the uterus | 48 | 38 | 21.1 | 26.3 | 34.2 | 18.4 | 78.9 | |
Endometrial clear cell carcinoma | 8 | 7 | 0.0 | 57.1 | 42.9 | 0.0 | 100.0 | |
Endometrial carcinoma, low differentiated G3 | 13 | 12 | 33.3 | 33.3 | 25.0 | 8.3 | 66.7 | |
Endometrial stromal sarcoma | 12 | 10 | 100.0 | 0.0 | 0.0 | 0.0 | 0.0 | |
Endometrioid carcinoma of the ovary | 115 | 86 | 1.2 | 4.7 | 26.7 | 67.4 | 98.8 | |
Serous carcinoma of the ovary | 567 | 495 | 0.8 | 13.7 | 31.9 | 53.5 | 99.2 | |
Mucinous carcinoma of the ovary | 97 | 75 | 0.0 | 17.3 | 18.7 | 64.0 | 100.0 | |
Clear cell carcinoma of the ovary | 54 | 47 | 8.5 | 34.0 | 31.9 | 25.5 | 91.5 | |
Carcinosarcoma of the ovary | 47 | 41 | 22.0 | 14.6 | 24.4 | 39.0 | 78.0 | |
Brenner tumor | 9 | 8 | 62.5 | 37.5 | 0.0 | 0.0 | 37.5 | |
Tumors of the breast | Invasive breast carcinoma of no special type | 1391 | 1001 | 3.6 | 21.8 | 23.5 | 50.9 | 96.2 |
Lobular carcinoma of the breast | 294 | 229 | 0.4 | 21.0 | 26.6 | 52.0 | 99.6 | |
Medullary carcinoma of the breast | 26 | 22 | 59.1 | 18.2 | 9.1 | 13.6 | 40.9 | |
Tubular carcinoma of the breast | 27 | 17 | 0.0 | 23.5 | 17.6 | 58.8 | 100.0 | |
Mucinous carcinoma of the breast | 58 | 35 | 0.0 | 11.4 | 37.1 | 51.4 | 100.0 | |
Phyllodes tumor of the breast | 50 | 32 | 0.0 | 37.5 | 21.9 | 40.6 | 100.0 | |
Tumors of the digestive system | Adenomatous polyp, low-grade dysplasia | 50 | 41 | 0.0 | 0.0 | 0.0 | 100.0 | 100.0 |
Adenomatous polyp, high-grade dysplasia | 50 | 44 | 0.0 | 0.0 | 2.3 | 97.7 | 100.0 | |
Adenocarcinoma of the colon | 1932 | 1750 | 2.6 | 2.3 | 9.9 | 85.3 | 97.4 | |
Adenocarcinoma of the small intestine | 10 | 5 | 0.0 | 0.0 | 0.0 | 100.0 | 100.0 | |
Gastric adenocarcinoma, diffuse type | 226 | 161 | 5.6 | 32.3 | 28.6 | 33.5 | 94.4 | |
Gastric adenocarcinoma, intestinal type | 224 | 156 | 7.1 | 23.7 | 19.2 | 50.0 | 92.9 | |
Gastric adenocarcinoma, mixed type | 62 | 59 | 5.1 | 25.4 | 22.0 | 47.5 | 94.9 | |
Adenocarcinoma of the esophagus | 133 | 70 | 1.4 | 12.9 | 7.1 | 78.6 | 98.6 | |
Squamous cell carcinoma of the esophagus | 124 | 63 | 68.3 | 22.2 | 0.0 | 9.5 | 31.7 | |
Squamous cell carcinoma of the anal canal | 50 | 33 | 75.8 | 15.2 | 9.1 | 0.0 | 24.2 | |
Cholangiocarcinoma | 130 | 112 | 1.8 | 17.0 | 29.5 | 51.8 | 98.2 | |
Hepatocellular carcinoma | 50 | 49 | 8.2 | 28.6 | 20.4 | 42.9 | 91.8 | |
Ductal adenocarcinoma of the pancreas | 612 | 523 | 1.0 | 16.8 | 25.6 | 56.6 | 99.0 | |
Pancreatic/Ampullary adenocarcinoma | 89 | 76 | 5.3 | 6.6 | 25.0 | 63.2 | 94.7 | |
Acinar cell carcinoma of the pancreas | 13 | 12 | 0.0 | 0.0 | 16.7 | 83.3 | 100.0 | |
Gastrointestinal stromal tumor (GIST) | 50 | 42 | 97.6 | 2.4 | 0.0 | 0.0 | 2.4 | |
Tumors of the urinary system | Non-invasive papillary urothelial carcinoma, pTa G2 low grade | 177 | 109 | 41.3 | 11.9 | 23.9 | 22.9 | 58.7 |
Non-invasive papillary urothelial carcinoma, pTa G2 high grade | 141 | 100 | 36.0 | 20.0 | 24.0 | 20.0 | 64.0 | |
Non-invasive papillary urothelial carcinoma, pTa G3 | 187 | 144 | 18.8 | 27.8 | 24.3 | 29.2 | 81.3 | |
Urothelial carcinoma, pT2-4 G3 | 1164 | 939 | 39.7 | 28.1 | 14.7 | 17.5 | 60.3 | |
Small cell neuroendocrine carcinoma of the bladder | 18 | 18 | 33.3 | 33.3 | 11.1 | 22.2 | 66.7 | |
Sarcomatoid urothelial carcinoma | 25 | 18 | 66.7 | 33.3 | 0.0 | 0.0 | 33.3 | |
Clear cell renal cell carcinoma | 858 | 722 | 47.5 | 31.2 | 14.3 | 7.1 | 52.5 | |
Papillary renal cell carcinoma | 255 | 209 | 2.4 | 15.3 | 15.8 | 66.0 | 97.1 | |
Chromophobe renal cell carcinoma | 131 | 112 | 0.9 | 9.8 | 20.5 | 68.8 | 99.1 | |
Oncocytoma | 177 | 144 | 1.4 | 11.8 | 16.7 | 69.4 | 97.9 | |
Clear cell (tubulo) papillary renal cell carcinoma | 21 | 18 | 27.8 | 5.6 | 16.7 | 50.0 | 72.2 | |
Tumors of the male genital organs | Adenocarcinoma of the prostate, Gleason 3 + 3 | 83 | 82 | 0.0 | 1.2 | 1.2 | 97.6 | 100.0 |
Adenocarcinoma of the prostate, Gleason 4 + 4 | 80 | 73 | 0.0 | 4.1 | 1.4 | 94.5 | 100.0 | |
Adenocarcinoma of the prostate, Gleason 5 + 5 | 85 | 81 | 0.0 | 3.7 | 11.1 | 85.2 | 100.0 | |
Adenocarcinoma of the prostate (recurrence) | 330 | 287 | 6.3 | 16.0 | 27.9 | 49.8 | 93.7 | |
Small cell neuroendocrine carcinoma of the prostate | 17 | 16 | 25.0 | 18.8 | 37.5 | 18.8 | 75.0 | |
Seminoma | 220 | 204 | 97.5 | 2.5 | 0.0 | 0.0 | 2.5 | |
Germ cell neoplasia in situ | 85 | 67 | 64.2 | 29.9 | 3.0 | 3.0 | 35.8 | |
Embryonal carcinoma of the testis | 50 | 46 | 0.0 | 23.9 | 19.6 | 56.5 | 100.0 | |
Yolk sack tumor | 50 | 42 | 0.0 | 38.1 | 21.4 | 40.5 | 100.0 | |
Teratoma | 50 | 27 | 70.4 | 14.8 | 0.0 | 14.8 | 29.6 | |
Tumors of endocrine organs | Adenoma of the thyroid gland | 114 | 109 | 0.0 | 5.5 | 35.8 | 58.7 | 100.0 |
Papillary thyroid carcinoma | 392 | 381 | 0.3 | 1.6 | 14.7 | 83.5 | 99.7 | |
Follicular thyroid carcinoma | 158 | 150 | 0.0 | 2.0 | 34.0 | 64.0 | 100.0 | |
Medullary thyroid carcinoma | 107 | 98 | 1.0 | 6.1 | 33.7 | 59.2 | 99.0 | |
Anaplastic thyroid carcinoma | 45 | 43 | 41.9 | 32.6 | 14.0 | 11.6 | 58.1 | |
Adrenal cortical adenoma | 50 | 36 | 91.7 | 5.6 | 0.0 | 2.8 | 8.3 | |
Adrenal cortical carcinoma | 26 | 20 | 70.0 | 10.0 | 0.0 | 20.0 | 30.0 | |
Phaeochromocytoma | 50 | 42 | 100.0 | 0.0 | 0.0 | 0.0 | 0.0 | |
Appendix, neuroendocrine tumor (NET) | 22 | 15 | 0.0 | 8.3 | 0.0 | 91.7 | 100.0 | |
Colorectal, neuroendocrine tumor (NET) | 10 | 10 | 0.0 | 0.0 | 10.0 | 90.0 | 100.0 | |
Ileum, neuroendocrine tumor (NET) | 49 | 45 | 0.0 | 2.2 | 2.2 | 95.6 | 100.0 | |
Lung, neuroendocrine tumor (NET) | 19 | 18 | 0.0 | 11.8 | 17.6 | 70.6 | 100.0 | |
Pancreas, neuroendocrine tumor (NET) | 102 | 79 | 1.3 | 5.1 | 31.6 | 62.0 | 98.7 | |
Colorectal, neuroendocrine carcinoma (NEC) | 11 | 9 | 33.3 | 22.2 | 22.2 | 22.2 | 66.7 | |
Gallbladder, neuroendocrine carcinoma (NEC) | 4 | 4 | 50.0 | 0.0 | 25.0 | 25.0 | 50.0 | |
Pancreas, neuroendocrine carcinoma (NEC) | 13 | 7 | 28.6 | 28.6 | 0.0 | 42.9 | 71.4 | |
Tumors of haemotopoetic and lymphoid tissues | Hodgkin Lymphoma | 45 | 39 | 100.0 | 0.0 | 0.0 | 0.0 | 0.0 |
Non-Hodgkin Lymphoma | 48 | 41 | 100.0 | 0.0 | 0.0 | 0.0 | 0.0 | |
Tumors of soft tissue and bone | Tenosynovial giant cell tumor | 45 | 43 | 100.0 | 0.0 | 0.0 | 0.0 | 0.0 |
Granular cell tumor | 53 | 32 | 100.0 | 0.0 | 0.0 | 0.0 | 0.0 | |
Leiomyoma | 50 | 32 | 100.0 | 0.0 | 0.0 | 0.0 | 0.0 | |
Angiomyolipoma | 91 | 74 | 98.6 | 1.4 | 0.0 | 0.0 | 1.4 | |
Angiosarcoma | 73 | 55 | 87.3 | 7.3 | 3.6 | 1.8 | 12.7 | |
Dermatofibrosarcoma protuberans | 21 | 16 | 100.0 | 0.0 | 0.0 | 0.0 | 0.0 | |
Ganglioneuroma | 14 | 11 | 100.0 | 0.0 | 0.0 | 0.0 | 0.0 | |
Kaposi sarcoma | 8 | 5 | 100.0 | 0.0 | 0.0 | 0.0 | 0.0 | |
Leiomyosarcoma | 87 | 70 | 100.0 | 0.0 | 0.0 | 0.0 | 0.0 | |
Liposarcoma | 132 | 98 | 100.0 | 0.0 | 0.0 | 0.0 | 0.0 | |
Malignant peripheral nerve sheath tumor (MPNST) | 13 | 12 | 100.0 | 0.0 | 0.0 | 0.0 | 0.0 | |
Myofibrosarcoma | 26 | 24 | 100.0 | 0.0 | 0.0 | 0.0 | 0.0 | |
Neurofibroma | 117 | 103 | 100.0 | 0.0 | 0.0 | 0.0 | 0.0 | |
Sarcoma, not otherwise specified (NOS) | 75 | 67 | 94.0 | 4.5 | 1.5 | 0.0 | 6.0 | |
Paraganglioma | 41 | 37 | 100.0 | 0.0 | 0.0 | 0.0 | 0.0 | |
Primitive neuroectodermal tumor (PNET) | 23 | 13 | 100.0 | 0.0 | 0.0 | 0.0 | 0.0 | |
Rhabdomyosarcoma | 7 | 6 | 100.0 | 0.0 | 0.0 | 0.0 | 0.0 | |
Schwannoma | 121 | 93 | 98.9 | 0.0 | 1.1 | 0.0 | 1.1 | |
Synovial sarcoma | 12 | 10 | 100.0 | 0.0 | 0.0 | 0.0 | 0.0 | |
Osteosarcoma | 43 | 29 | 96.6 | 3.4 | 0.0 | 0.0 | 3.4 | |
Chondrosarcoma | 39 | 21 | 100.0 | 0.0 | 0.0 | 0.0 | 0.0 |