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Table 2 Cytokeratin 18 immunostaining and tumor phenotype

From: Diagnostic and prognostic impact of cytokeratin 18 expression in human tumors: a tissue microarray study on 11,952 tumors

  n CK18 Immunostaining p
Negative (%) Weak (%) Moderate (%) Strong (%)
Invasive breast carcinoma of no special type       
 All cancers 935 3.6 22.2 23.9 50.3  
 pT1 497 4.2 18.9 25.0 51.9 0.0611
 pT2 333 2.4 26.1 23.7 47.8  
 pT3-4 73 6.9 19.2 16.4 57.5  
 Grade 1 147 0.0 16.3 21.1 62.6  < 0.0001
 Grade 2 479 2.1 19.0 26.7 52.2  
 Grade 3 308 7.8 30.2 20.5 41.6  
 pN0 439 3.2 20.1 23.9 52.9 0.6092
pN+ 299 2.7 23.1 25.8 48.5  
 HER2 negative 697 4.0 20.8 22.0 53.2 0.1689
 HER2 positive 89 1.1 18.0 30.3 50.6  
 ER negative 160 15.0 33.8 23.1 28.1  < 0.0001
 ER positive 589 0.5 16.6 22.8 60.1  
 PR negative 308 8.8 28.6 24.0 38.6  < 0.0001
 PR positive 472 0.4 15.7 22.7 61.2  
 Non-triple negative 619 0.8 17.5 22.5 59.3  < 0.0001
 Triple negative 107 20.6 37.4 21.5 20.6  
Clear cell renal cell carcinoma       
 All cancers 674 48.7 30.4 14.1 6.8  
 ISUP 1 217 42.9 35.5 15.2 6.5 0.1312
 ISUP 2 218 50.5 28.4 13.8 7.3  
 ISUP 3 189 51.3 30.2 13.2 5.3  
 ISUP 4 40 67.5 17.5 5.0 10.0  
 Fuhrmann 1 32 37.5 34.4 21.9 6.3 0.2311
 Fuhrmann 2 399 46.4 31.6 15.0 7.0  
 Fuhrmann 3 194 52.1 30.9 11.3 5.7  
 Fuhrmann 4 48 62.5 16.7 10.4 10.4  
 Thoenes 1 239 41.0 33.9 17.6 7.5 0.0086
 Thoenes 2 369 51.8 30.1 12.7 5.4  
 Thoenes 3 65 60.0 20.0 7.7 12.3  
 UICC 1 294 37.4 36.1 19.0 7.5 0.0010
 UICC 2 34 50.0 32.4 11.8 5.9  
 UICC 3 87 58.6 20.7 11.5 9.2  
 UICC 4 70 57.1 34.3 7.1 1.4  
 pT1 391 40.2 35.8 16.1 7.9  < 0.0001
 pT2 72 59.7 25.0 11.1 4.2  
 pT3 206 61.7 21.4 11.2 5.8  
 pN0 114 55.3 28.9 7.9 7.9 0.5327
 pN+  16 43.8 25.0 18.8 12.5  
 pM0 102 39.2 35.3 15.7 9.8  < 0.0001
 pM +  73 64.4 31.5 4.1 0.0  
Urinary bladder cancer       
 All cancers 1353 37.0 25.4 18.0 19.7  
 pTa G2 low 109 41.3 11.9 23.9 22.9  < 0.0001
 pTa G2 high 100 36.0 20.0 24.0 20.0  
 pTaG3 144 18.8 27.8 24.3 29.2  
 pT ≥ 2 G3 921 39.9 28.0 14.8 17.4  
 pT ≥ 2 G3 sarcomatoid 18 33.3 33.3 11.1 22.2  
 pT ≥ 2 G3 small cell cancer 18 66.7 33.3 0.0 0.0  
 pN0 293 36.5 26.6 16.7 20.1 0.2540
 pN+ 170 27.7 29.4 18.2 24.7  
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