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Table 2 Cytokeratin 18 immunostaining and tumor phenotype

From: Diagnostic and prognostic impact of cytokeratin 18 expression in human tumors: a tissue microarray study on 11,952 tumors

 

n

CK18 Immunostaining

p

Negative (%)

Weak (%)

Moderate (%)

Strong (%)

Invasive breast carcinoma of no special type

      

 All cancers

935

3.6

22.2

23.9

50.3

 

 pT1

497

4.2

18.9

25.0

51.9

0.0611

 pT2

333

2.4

26.1

23.7

47.8

 

 pT3-4

73

6.9

19.2

16.4

57.5

 

 Grade 1

147

0.0

16.3

21.1

62.6

 < 0.0001

 Grade 2

479

2.1

19.0

26.7

52.2

 

 Grade 3

308

7.8

30.2

20.5

41.6

 

 pN0

439

3.2

20.1

23.9

52.9

0.6092

pN+

299

2.7

23.1

25.8

48.5

 

 HER2 negative

697

4.0

20.8

22.0

53.2

0.1689

 HER2 positive

89

1.1

18.0

30.3

50.6

 

 ER negative

160

15.0

33.8

23.1

28.1

 < 0.0001

 ER positive

589

0.5

16.6

22.8

60.1

 

 PR negative

308

8.8

28.6

24.0

38.6

 < 0.0001

 PR positive

472

0.4

15.7

22.7

61.2

 

 Non-triple negative

619

0.8

17.5

22.5

59.3

 < 0.0001

 Triple negative

107

20.6

37.4

21.5

20.6

 

Clear cell renal cell carcinoma

      

 All cancers

674

48.7

30.4

14.1

6.8

 

 ISUP 1

217

42.9

35.5

15.2

6.5

0.1312

 ISUP 2

218

50.5

28.4

13.8

7.3

 

 ISUP 3

189

51.3

30.2

13.2

5.3

 

 ISUP 4

40

67.5

17.5

5.0

10.0

 

 Fuhrmann 1

32

37.5

34.4

21.9

6.3

0.2311

 Fuhrmann 2

399

46.4

31.6

15.0

7.0

 

 Fuhrmann 3

194

52.1

30.9

11.3

5.7

 

 Fuhrmann 4

48

62.5

16.7

10.4

10.4

 

 Thoenes 1

239

41.0

33.9

17.6

7.5

0.0086

 Thoenes 2

369

51.8

30.1

12.7

5.4

 

 Thoenes 3

65

60.0

20.0

7.7

12.3

 

 UICC 1

294

37.4

36.1

19.0

7.5

0.0010

 UICC 2

34

50.0

32.4

11.8

5.9

 

 UICC 3

87

58.6

20.7

11.5

9.2

 

 UICC 4

70

57.1

34.3

7.1

1.4

 

 pT1

391

40.2

35.8

16.1

7.9

 < 0.0001

 pT2

72

59.7

25.0

11.1

4.2

 

 pT3

206

61.7

21.4

11.2

5.8

 

 pN0

114

55.3

28.9

7.9

7.9

0.5327

 pN+ 

16

43.8

25.0

18.8

12.5

 

 pM0

102

39.2

35.3

15.7

9.8

 < 0.0001

 pM + 

73

64.4

31.5

4.1

0.0

 

Urinary bladder cancer

      

 All cancers

1353

37.0

25.4

18.0

19.7

 

 pTa G2 low

109

41.3

11.9

23.9

22.9

 < 0.0001

 pTa G2 high

100

36.0

20.0

24.0

20.0

 

 pTaG3

144

18.8

27.8

24.3

29.2

 

 pT ≥ 2 G3

921

39.9

28.0

14.8

17.4

 

 pT ≥ 2 G3 sarcomatoid

18

33.3

33.3

11.1

22.2

 

 pT ≥ 2 G3 small cell cancer

18

66.7

33.3

0.0

0.0

 

 pN0

293

36.5

26.6

16.7

20.1

0.2540

 pN+

170

27.7

29.4

18.2

24.7